SM4455 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Lauric acid 0
siRNA modification types 1 0
Overall number of modifications 1 0
Position of modifications 1 0
Modification on sugar or base or phosphate Phosphate 0
SMILES
(Click to view structure & nomenclature)
CCCCCCCCCCCC(=O)NCCCCCCO



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siRNA Sequence GGCCUUUCACUACUCCUACGA GUAGGAGUAGUGAAAGGCCAG
siRNA length base-pair 21 21
siRNA name in paper C12-siLuc C12-siLuc
Biological activity 87 percent target mRNA inhibition
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene Renilla luciferase
siRNA concentration 1 nM
Cell or Organism used HeLa cells
Transfection method Lipofectamine 2000
Duration after transfection 48 Hours
Article title Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity
Reference21985606