SM4456 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 Palmitic Acid
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 21
Modification on sugar or base or phosphate 0 Phosphate
SMILES
(Click to view structure & nomenclature)
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CCCCCCCCCCCCCCCC(=O)NCCCCCCO



siRNA Sequence GGCCUUUCACUACUCCUACGA GUAGGAGUAGUGAAAGGCCAG
siRNA length base-pair 21 21
siRNA name in paper siLuc- C16 siLuc- C16
Biological activity 82 percent target mRNA inhibition
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene Renilla luciferase
siRNA concentration 1 nM
Cell or Organism used HeLa cells
Transfection method Lipofectamine 2000
Duration after transfection 48 Hours
Article title Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity
Reference21985606