SM4458 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Palmitic acid 0
siRNA modification types 1 0
Overall number of modifications 1 0
Position of modifications 1 0
Modification on sugar or base or phosphate Phosphate 0
SMILES
(Click to view structure & nomenclature)
CCCCCCCCCCCCCCCC(=O)NCCCCCCO



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siRNA Sequence GGCCUUUCACUACUCCUACGA GUAGGAGUAGUGAAAGGCCAG
siRNA length base-pair 21 21
siRNA name in paper C16-siLuc C16-siLuc
Biological activity 6 percent target mRNA inhibition
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene Renilla luciferase
siRNA concentration 100 nM
Cell or Organism used HeLa cells
Transfection method Absence of Lipofectamine 2000
Duration after transfection 48 Hours
Article title Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity
Reference21985606