SM4480 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 2-Deoxyribonucleotide 2-Deoxyribonucleotide
siRNA modification types 1 1
Overall number of modifications 2 2
Position of modifications 20,21 20,21
Modification on sugar or base or phosphate Sugar Sugar
SMILES
(Click to view structure & nomenclature)
OCC1OCCC1O



OCC1OCCC1O



siRNA Sequence UCCUACAGCACAACAAAUGUG CAUUUGUUGUGCUGUAGGAAG
siRNA length base-pair 21 21
siRNA name in paper siVEGF-dT siVEGF-dT
Biological activity 0 percent target mRNA inhibition
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene vascular endothelial growth factor (VEGF) gene
siRNA concentration 1 uM
Cell or Organism used HeLa cells
Transfection method Absence of Lipofectamine 2000
Duration after transfection 120 Hours
Article title Palmitic acid-conjugated 21-nucleotide siRNA enhances gene-silencing activity
Reference21985606