SM4534 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 2-Deoxyribonucleotide 0
siRNA modification types 1 0
Overall number of modifications 2 0
Position of modifications 24,25 0
Modification on sugar or base or phosphate Sugar 0
SMILES
(Click to view structure & nomenclature)
OCC1OCCC1O



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siRNA Sequence GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG
siRNA length base-pair 25 27
siRNA name in paper DsiRNA-A DsiRNA-A
Biological activity 70 percent target mRNA inhibition
Experiment used to check activity Luciferase gene reporter assay
Melting temperature (oC) NA
Target gene Renilla luciferase gene
siRNA concentration 0.2 nM
Cell or Organism used HeLa cells
Transfection method Lipofectamine 2000
Duration after transfection 48 Hours
Article title Amino-modified and lipid-conjugated dicer-substrate siRNA enhances RNAi efficacy
Reference22236254