| Field | Sense | Antisense |
| siRNA chemical modification | Triazole-linked nucleic acid | Triazole-linked nucleic acid |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 1 | 1 |
| Position of modifications | 20 | 20 |
| Modification on sugar or base or phosphate | Backbone | Backbone |
| SMILES (Click to view structure & nomenclature) |
CCN(CCN1C=C(CN(CC)C(C)=O)N=N1)C(C)=O |
CCN(CCN1C=C(CN(CC)C(C)=O)N=N1)C(C)=O |
| siRNA Sequence | CUUACGCUGAGUACUUCGATT | UCGAAGUACUCAGCGUAAGTT |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | 18 | 18 |
| Biological activity | 76 percent target mRNA inhibition | |
| Experiment used to check activity | Luciferase gene reporter assay | |
| Melting temperature (oC) | 72.5 | |
| Target gene | Firefly luciferase | |
| siRNA concentration | 0.008 nM | |
| Cell or Organism used | HeLa cells | |
| Transfection method | NA | |
| Duration after transfection | 24 Hours | |
| Article title | Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages |
|
| Reference | 22260772 | |