SM4641 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Lauric acid 0
siRNA modification types 1 0
Overall number of modifications 1 0
Position of modifications 1 0
Modification on sugar or base or phosphate Phosphate 0
SMILES
(Click to view structure & nomenclature)
CCCCCCCCCCCC(=O)NCCCCCCO



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siRNA Sequence CUGGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG
siRNA length base-pair 27 27
siRNA name in paper C12-ds27Luc C12-ds27Luc
Biological activity 2 percent target mRNA inhibition
Experiment used to check activity Dual-Glo Luciferase Assay System
Melting temperature (oC) NA
Target gene Renilla luciferase gene
siRNA concentration 600 nM
Cell or Organism used HeLa cells
Transfection method No transfection agent
Duration after transfection 48 Hours
Article title Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing
Reference22494497