SM4656 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Palmitic acid 0
siRNA modification types 1 0
Overall number of modifications 1 0
Position of modifications 1 0
Modification on sugar or base or phosphate Phosphate 0
SMILES
(Click to view structure & nomenclature)
CCCCCCCCCCCCCCCC(=O)NCCCCCCO



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siRNA Sequence UCCUACAGCACAACAAAUGUG CAUUUGUUGUGCUGUAGGAAG
siRNA length base-pair 21 21
siRNA name in paper C16-ss21VEGF C16-ss21VEGF
Biological activity 15 percent target mRNA inhibition
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene VEGF
siRNA concentration 100 nM
Cell or Organism used HeLa cells
Transfection method No transfection agent
Duration after transfection 48 Hours
Article title Lipid-conjugated 27-nucleotide double-stranded RNAs with dicer-substrate potency enhance RNAi-mediated gene silencing
Reference22494497