SM4676 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 Locked nucleic acid
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 17
Modification on sugar or base or phosphate 0 Sugar
SMILES
(Click to view structure & nomenclature)
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OCC12COC(CO1)C2O



siRNA Sequence CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT
siRNA length base-pair 21 21
siRNA name in paper 17 17
Biological activity 93 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay 
Melting temperature (oC) NA
Target gene Renilla luciferase
siRNA concentration 13 nM
Cell or Organism used HEK293 cells
Transfection method Lipofectamine 2000
Duration after transfection NA
Article title Modified Short Interfering Rna (Modified Sirna)
Reference US 20080249039 A1