SM4683 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Locked nucleic acid 0
siRNA modification types 1 0
Overall number of modifications 4 0
Position of modifications 1,2,13,14 0
Modification on sugar or base or phosphate Sugar 0
SMILES
(Click to view structure & nomenclature)
OCC12COC(CO1)C2O



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siRNA Sequence NNNNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNN
siRNA length base-pair 21 21
siRNA name in paper H H
Biological activity 80 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay 
Melting temperature (oC) NA
Target gene Forward orientation fLuc mRNA
siRNA concentration 30 nM
Cell or Organism used HeLa cells
Transfection method siPROT Amine transfection agent
Duration after transfection 48 Hours
Article title Sirna sequence-independent modification formats for reducing off-target phenotypic effects in rnai, and stabilized forms thereof
ReferenceEP2548962A1