| Field | Sense | Antisense |
| siRNA chemical modification | 2-O-Methylribose | 2-O-Methylribose |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 9 | 7 |
| Position of modifications | 2,4,6,8,10,12,14,16,18 | 6,7,10,11,17,18,19 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
COC1C(O)OC(CO)C1O |
COC1C(O)OC(CO)C1O |
| siRNA Sequence | GGAGAUCAACAUUUUCAAA | UUUGAAAAUGUUGAUCUCC |
| siRNA length base-pair | 19 | 19 |
| siRNA name in paper | 352511 | 352506 |
| Biological activity | IC-50 = 0.045167 nM for target mRNA | |
| Experiment used to check activity | RT-PCR | |
| Melting temperature (oC) | NA | |
| Target gene | Survivin | |
| siRNA concentration | 50 nM | |
| Cell or Organism used | HeLa cells | |
| Transfection method | LIPOFECTIN | |
| Duration after transfection | 16 Hours | |
| Article title | Positionally modified siRNA constructs |
|
| Reference | US 8394947 B2 | |