| Field | Sense | Antisense |
| siRNA chemical modification | Phosphorothioate | Phosphorothioate |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 1 | 1 |
| Position of modifications | 20 | 20 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
OCC1OCC(O)C1OP(O)(S)=O |
OCC1OCC(O)C1OP(O)(S)=O |
| siRNA Sequence | GGAUCAUCUCAAGUCUUACTT | GUAAGACUUGAGAUGAUCCTT |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | I | I |
| Biological activity | IC-50 = 0.0095 nM for target mRNA | |
| Experiment used to check activity | 4 parameter fit model | |
| Melting temperature (oC) | 71.8 | |
| Target gene | Target gene | |
| siRNA concentration | 10 nM | |
| Cell or Organism used | Hep3B cells or rat H.II.4.E cells | |
| Transfection method | Lipofectamine RNAiMax | |
| Duration after transfection | 24 Hoursrs | |
| Article title | Modified rnai agents |
|
| Reference | WO2014022739A3 | |