SM4833 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 unlocked nucleic acid
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 1
Modification on sugar or base or phosphate 0 Sugar
SMILES
(Click to view structure & nomenclature)
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OCCOC(CO)CO



siRNA Sequence UGAAUCAGAAGAUGAAGUCAA GACUUCAUCUUCUGAUUCAAG
siRNA length base-pair 21 21
siRNA name in paper 5AS_UsiH5 5AS_UsiH5
Biological activity 92 percent target mRNA inhibition
Experiment used to check activity Dual luciferase assay
Melting temperature (oC) NA
Target gene Sensor for S strand luciferase gene
siRNA concentration 2 nmol/l
Cell or Organism used HEK293 cells
Transfection method RNAiMAX
Duration after transfection 24 Hoursrs
Article title 5' Unlocked Nucleic Acid Modification Improves siRNA Targeting
Reference23820891