SM4848 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification DeoxyThymidine DeoxyThymidine
siRNA modification types 1 1
Overall number of modifications 2 2
Position of modifications 20,21 20,21
Modification on sugar or base or phosphate Sugar Sugar
SMILES
(Click to view structure & nomenclature)
CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O



CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O



siRNA Sequence GUAUCUCUUCAUAGCCUUATT UAAGGCUAUGAAGAGAUACTT
siRNA length base-pair 21 21
siRNA name in paper siNTCtrl siNTCtrl
Biological activity NA
Experiment used to check activity Quantitative PCR analysis
Melting temperature (oC) N.D.
Target gene apoB gene
siRNA concentration 10nM/L
Cell or Organism used NMuLi cells
Transfection method Lipofectamine RNAiMAX
Duration after transfection NA
Article title Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo
Reference23344237