SM4890 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 4-Thioribose
siRNA modification types 0 1
Overall number of modifications 0 4
Position of modifications 0 16,17,18,19
Modification on sugar or base or phosphate 0 Sugar
SMILES
(Click to view structure & nomenclature)
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OCC1SCC(O)C1O



siRNA Sequence AAACAUGCAGAAAAUGCUGTT CAGCAUUUUCUGCAUGUUUTT
siRNA length base-pair 21 21
siRNA name in paper RNA14 RNA14
Biological activity 52.7 percent target mRNA inhibition
Experiment used to check activity Dual luciferase assay
Melting temperature (oC) NA
Target gene Renilla luciferase gene
siRNA concentration 25 nM
Cell or Organism used NIH/3T3 cells
Transfection method NA
Duration after transfection 24 Hours
Article title RNA interference induced by siRNAs modified with 4'-thioribonucleosides
Reference17150641