| Field | Sense | Antisense |
| siRNA chemical modification | 4-Thioribose | 4-Thioribose |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 2 | 2 |
| Position of modifications | 1,2 | 18,19 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
OCC1SCC(O)C1O |
OCC1SCC(O)C1O |
| siRNA Sequence | AAACAUGCAGAAAAUGCUGTT | CAGCAUUUUCUGCAUGUUUTT |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | RNA15 | RNA15 |
| Biological activity | 72.4 percent target mRNA inhibition | |
| Experiment used to check activity | Dual luciferase assay | |
| Melting temperature (oC) | NA | |
| Target gene | Renilla luciferase gene | |
| siRNA concentration | 25 nM | |
| Cell or Organism used | NIH/3T3 cells | |
| Transfection method | NA | |
| Duration after transfection | 24 Hours | |
| Article title | RNA interference induced by siRNAs modified with 4'-thioribonucleosides |
|
| Reference | 17150641 | |