| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| ASPsiRNA ID | Mutant allele/ASP-siRNA | Efficacy for mutant(%) |
Efficacy for wild (%) |
Relative Difference (%) | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
| aspsirna0190 | UGAAGUGAAGAUGGAUGCAG ACUUCACUUCUACCUACGUC |
83 | Poor efficacy | High discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 | 
|
|
| aspsirna0191 | AAGUGAAGAUGGAUGCAGAAUUC UUCACUUCUACCUACGUCUUAAG |
NA | NA | NA | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0192 | AAGUGAAUCUGGAUGCAGAA UUCACUUAGACCUACGUCUU |
12 | Poor efficacy | Lowest discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0193 | GAAGUGAAUCUGGAUGCAGA CUUCACUUAGACCUACGUCU |
65 | Poor efficacy | High discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0194 | UGAAGUGAAUCUGGAUGCAG ACUUCACUUAGACCUACGUC |
0 | Poor efficacy | Lowest discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0195 | CUGAAGUGAAUCUGGAUGCA GACUUCACUUAGACCUACGU |
45 | Poor efficacy | Moderate discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0196 | UCUGAAGUGAAUCUGGAUGC AGACUUCACUUAGACCUACG |
84 | 82 | 2 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0197 | GUGGCCAGAUGGAAGUAAAAUC CACCGGUCUACCUUCAUUUUAG |
65 | 60 | 5 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
|
| aspsirna0198 | GUGGCCAGGAGGAAGUAAAAUC CACCGGUCCUCCUUCAUUUUAG |
77 | Poor efficacy | High discrimination | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
|
| aspsirna0199 | GUGGCCAGGUAGAAGUAAAAUC CACCGGUCCAUCUUCAUUUUAG |
86 | Poor efficacy | High discrimination | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|
|
| aspsirna0200 | GUGGCCAGGUGAAAGUAAAAUC CACCGGUCCACUUUCAUUUUAG |
93 | 80 | 13 | MAPT | Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) | c.1960G>A,p.Val654Met | rs63750570 |
|