| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0040 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-O-Methyl |
10 * 21,22
2 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0086 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-O-Methyl* 2-Aminoethyl |
10 * 21,22
1 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0131 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-O-Methyl* 2-Cyanoethyl |
10 * 21,22
1 * 18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0176 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
10 * 21,22
1,2 |
Sugar
Sugar |
7.2 percent target mRNA inhibition | 19282453 |
| SM0221 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
10 * 21,22
20,21 |
Sugar
Sugar |
72.3 percent target mRNA inhibition | 19282453 |
| SM0266 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
10 * 21,22
5,8,11,14,17,20 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0311 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
Altritol nucleic acid |
10 * 21,22
3,6,14,18,20,21 |
Sugar
Sugar |
11 percent target mRNA inhibition | 19282453 |
| SM0356 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
10 * 21,22
18,19,20 * 21 |
Sugar
Sugar |
6.2 percent target mRNA inhibition | 19282453 |
| SM0401 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
10 * 21,22
2,18,19,20 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0446 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
10 * 21,22
3,18,19,20 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0491 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
10 * 21,22
2,9,18,19,20 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0536 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
2-Aminoethoxymethyl* 2-Deoxy |
10 * 21,22
18,19 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0581 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
UnLocked nucleic acid* Locked nucleic acid
2-Aminopropoxymethyl* 2-Deoxy |
10 * 21,22
18,19 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0626 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Fluoro* 2-O-Methyl |
10 * 21,22
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0671 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
10 * 21,22
3,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0716 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
10 * 21,22
4,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0761 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid |
10 * 21,22
3,4,18 |
Sugar
Sugar |
2 percent target mRNA inhibition | 19282453 |
| SM0806 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
10 * 21,22
3,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0851 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
10 * 21,22
4,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0896 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid |
10 * 21,22
3,4,18 |
Sugar
Sugar |
18 percent target mRNA inhibition | 19282453 |
| SM0941 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
10 * 21,22
3,18 |
Sugar
Sugar |
29.2 percent target mRNA inhibition | 19282453 |
| SM0986 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
10 * 21,22
4,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM1031 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGC |
UnLocked nucleic acid* Locked nucleic acid
2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid |
10 * 21,22
3,4,18 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM1076 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-Aminoethyl |
10 * 21,22
20,21 |
Sugar
Sugar |
50.9 percent target mRNA inhibition | 19282453 |
| SM1121 |
GACGUAAACCGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGCU |
UnLocked nucleic acid* Locked nucleic acid
2-Aminopropyl |
10 * 21,22
1 |
Sugar
Sugar |
8.3 percent target mRNA inhibition | 19282453 |