Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 16 * 17 * 20,21 are 4
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4402
    GUGAAGUCAACAUGCCUGCTT
    GCAGGCAUGUUGACUUCACTT
    Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine
    2-Deoxythymidine
    16 * 17 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    85 percent target mRNA inhibition
    25699137
    SM4403
    GUGAAGUCAACAUGCCUGCTT
    GCAGGCAUGUUGACUUCACTT
    Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine
    2-Deoxythymidine
    16 * 17 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    73 percent target mRNA inhibition
    25699137
    SM4409
    GUGAAGUCAACAUGCCUGCTT
    GCAGGCAUGUUGACUUCACTT
    Triazole-linked nucleic acid* Phenyl* 2-Deoxythymidine
    2-Deoxythymidine
    16 * 17 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    83 percent target mRNA inhibition
    25699137
    SM4410
    GUGAAGUCAACAUGCCUGCTT
    GCAGGCAUGUUGACUUCACTT
    Triazole-linked nucleic acid* Cholesterol* 2-Deoxythymidine
    2-Deoxythymidine
    16 * 17 * 20,21
    20,21
    Phosphate ; Base ; Sugar
    Sugar
    80 percent target mRNA inhibition
    25699137