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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 18 * 20,21 are 8
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4514
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    2-Deoxythymidine
    18 * 20,21
    20,21
    Sugar
    Sugar
    55 percent target mRNA inhibition
    17616127
    SM4520
    GAACUCUUAGCGUAUGCAATT
    UUGCAUACGCUAAGAGUUCTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    2-Deoxythymidine
    18 * 20,21
    20,21
    Sugar
    Sugar
    NA
    17616127
    SM4526
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    18 * 20,21
    12 * 20,21
    Sugar
    Sugar
    39 percent target mRNA inhibition
    17616127
    SM4527
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    18 * 20,21
    12 * 20,21
    Sugar
    Sugar
    43 percent target mRNA inhibition
    17616127
    SM4528
    GAACUCUUAGCGUAUGCAATT
    UUGCAUACGCUAAGAGUUCTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    18 * 20,21
    15 * 20,21
    Sugar
    Sugar
    46 percent target mRNA inhibition
    17616127
    SM4529
    GAACUCUUAGCGUAUGCAATT
    UUGCAUACGCUAAGAGUUCTT
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    Cyclohexenyl nucleic acid* 2-Deoxythymidine
    18 * 20,21
    15 * 20,21
    Sugar
    Sugar
    36 percent target mRNA inhibition
    17616127
    SM4591
    GGUCAUCCAUGACAACUUUTT
    AAAGUUGUCAUGGAUGACCTT
    Triazole-linked nucleic acid* 2-Deoxythymidine
    2-Deoxythymidine
    18 * 20,21
    20,21
    Sugar; Backbone
    Sugar
    85 percent target mRNA inhibition
    22260772
    SM4595
    GGUCAUCCAUGACAACUUUTT
    AAAGUUGUCAUGGAUGACCTT
    Triazole-linked nucleic acid* 2-Deoxythymidine
    2-Deoxythymidine
    18 * 20,21
    20,21
    Sugar; Backbone
    Sugar
    95 percent target mRNA inhibition
    22260772