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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 20 * 21 are 18
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4383	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	92 percent target mRNA inhibition	25699137
SM4384	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	85 percent target mRNA inhibition	25699137
SM4398	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	97 percent target mRNA inhibition	25699137
SM4399	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	95 percent target mRNA inhibition	25699137
SM4405	GUGAAGUCAACAUGCCUGCCU GCAGGCAUGUUGACUUCACTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	75 percent target mRNA inhibition	25699137
SM4406	GUGAAGUCAACAUGCCUGCCU GCAGGCAUGUUGACUUCACTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	76 percent target mRNA inhibition	25699137
SM4412	GUGAAGUCAACAUGCCUGCCU GCAGGCAUGUUGACUUCACTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	82 percent target mRNA inhibition	25699137
SM4413	GUGAAGUCAACAUGCCUGCCU GCAGGCAUGUUGACUUCACTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	10 percent target mRNA inhibition	25699137
SM4416	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	20 percent target mRNA inhibition	25699137
SM4417	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	30 percent target mRNA inhibition	25699137
SM4420	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	34 percent target mRNA inhibition	25699137
SM4421	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	82 percent target mRNA inhibition	25699137
SM4424	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Phenyl 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	63 percent target mRNA inhibition	25699137
SM4425	CUUACGCUGAGUACUUCGACU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* Cholesterol 2-Deoxythymidine	20 * 21 20,21	Phosphate ; Base Sugar	84 percent target mRNA inhibition	25699137
SM4464	UCCUACAGCACAACAAAUGUG CAUUUGUUGUGCUGUAGGATT	2-Deoxyribonucleotide* Inverted thymidine 2-Deoxyribonucleotide* Inverted thymidine	20 * 21 20 * 21	Sugar Sugar	65 percent target mRNA inhibition	21985606
SM4470	UCCUACAGCACAACAAAUGUG CAUUUGUUGUGCUGUAGGAAG	2-Deoxyribonucleotide* Inverted thymidine 2-Deoxyribonucleotide* Inverted thymidine	20 * 21 20 * 21	Sugar Sugar	55 percent target mRNA inhibition	21985606
SM4476	UCCUACAGCACAACAAAUGUG CAUUUGUUGUGCUGUAGGAAG	2-Deoxyribonucleotide* Inverted thymidine 2-Deoxyribonucleotide* Inverted thymidine	20 * 21 20 * 21	Sugar Sugar	12 percent target mRNA inhibition	21985606
SM4482	UCCUACAGCACAACAAAUGUG CAUUUGUUGUGCUGUAGGAAG	2-Deoxyribonucleotide* Inverted thymidine 2-Deoxyribonucleotide* Inverted thymidine	20 * 21 20 * 21	Sugar Sugar	0 percent target mRNA inhibition	21985606