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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 21 are 161
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0037	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2-O-Methyl	21 2	Sugar Sugar	80 percent target mRNA inhibition	19282453
SM0041	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-O-Methyl	21 2	Sugar Sugar	82 percent target mRNA inhibition	19282453
SM0083	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-O-Methyl* 2-Aminoethyl	21 1 * 21	Sugar Sugar	84.6 percent target mRNA inhibition	19282453
SM0087	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Aminoethyl	21 1 * 21	Sugar Sugar	87.9 percent target mRNA inhibition	19282453
SM0128	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-O-Methyl* 2-Cyanoethyl	21 1 * 18	Sugar Sugar	59.2 percent target mRNA inhibition	19282453
SM0132	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Cyanoethyl	21 1 * 18	Sugar Sugar	47.9 percent target mRNA inhibition	19282453
SM0173	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	21 1,2	Sugar Sugar	60.6 percent target mRNA inhibition	19282453
SM0177	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid Altritol nucleic acid	21 1,2	Sugar Sugar	62.4 percent target mRNA inhibition	19282453
SM0218	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	21 20,21	Sugar Sugar	88.6 percent target mRNA inhibition	19282453
SM0222	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	21 20,21	Sugar Sugar	89.2 percent target mRNA inhibition	19282453
SM0263	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	21 5,8,11,14,17,20	Sugar Sugar	7.7 percent target mRNA inhibition	19282453
SM0267	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	21 5,8,11,14,17,20	Sugar Sugar	6.2 percent target mRNA inhibition	19282453
SM0308	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Altritol nucleic acid	21 3,6,14,18,20,21	Sugar Sugar	80.7 percent target mRNA inhibition	19282453
SM0312	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	21 3,6,14,18,20,21	Sugar Sugar	82 percent target mRNA inhibition	19282453
SM0353	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	21 18,19,20 * 21	Sugar Sugar	84.1 percent target mRNA inhibition	19282453
SM0357	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 18,19,20 * 21	Sugar Sugar	84.5 percent target mRNA inhibition	19282453
SM0398	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	21 2,18,19,20 * 21	Sugar Sugar	79.1 percent target mRNA inhibition	19282453
SM0402	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 2,18,19,20 * 21	Sugar Sugar	85.3 percent target mRNA inhibition	19282453
SM0443	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	21 3,18,19,20 * 21	Sugar Sugar	80.8 percent target mRNA inhibition	19282453
SM0447	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 3,18,19,20 * 21	Sugar Sugar	87 percent target mRNA inhibition	19282453
SM0488	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid Hexitol nucleic acid* 2-Deoxy	21 2,9,18,19,20 * 21	Sugar Sugar	49 percent target mRNA inhibition	19282453
SM0492	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 2,9,18,19,20 * 21	Sugar Sugar	45.5 percent target mRNA inhibition	19282453
SM0533	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Aminoethoxymethyl* 2-Deoxy	21 18,19 * 21	Sugar Sugar	56.1 percent target mRNA inhibition	19282453
SM0537	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	21 18,19 * 21	Sugar Sugar	51.9 percent target mRNA inhibition	19282453
SM0578	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGT	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Aminopropoxymethyl* 2-Deoxy	21 18,19 * 21	Sugar Sugar	41.9 percent target mRNA inhibition	19282453



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