SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM2381 |
CUUCUUCGUCGAGACCAUGTY CAUGGUCUCGACGAAGAAGTY |
Glucosamine analogue Glucosamine analogue |
21 21 |
Base Base |
53 percent target mRNA inhibition | 23743279 |
SM2387 |
CUUCUUCGUCGAGACCAUGTX CAUGGUCUCGACGAAGAAGTX |
Thymidine analogue Thymidine analogue |
21 21 |
Base Base |
83 percent target mRNA inhibition | 23743279 |
SM2388 |
CUUCUUCGUCGAGACCAUGTY CAUGGUCUCGACGAAGAAGTY |
Glucosamine analogue Glucosamine analogue |
21 21 |
Base Base |
68 percent target mRNA inhibition | 23743279 |
SM2465 |
CGGAGGCUGGGAUGCCUUUTT AAAGGCAUCCCAGCCUCCGTT |
Assymetric siRNA (3-End Overhang) Assymetric siRNA (3-End Overhang) |
21 1 |
NA NA |
60 percent target mRNA inhibition | 23135004 |
SM2659 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids 0 |
21 0 |
Phosphate 0 |
82 percent target mRNA inhibition | 19325750 |
SM2661 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids Peptide nucleic acids |
21 21 |
Phosphate Phosphate |
81 percent target mRNA inhibition | 19325750 |
SM2663 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids 0 |
21 0 |
Phosphate 0 |
80 percent target mRNA inhibition | 19325750 |
SM2665 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids Peptide nucleic acids |
21 21 |
Phosphate Phosphate |
75 percent target mRNA inhibition | 19325750 |
SM2667 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids 0 |
21 0 |
Phosphate 0 |
80 percent target mRNA inhibition | 19325750 |
SM2669 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids Peptide nucleic acids |
21 21 |
Phosphate Phosphate |
80 percent target mRNA inhibition | 19325750 |
SM2671 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids 0 |
21 0 |
Phosphate 0 |
70 percent target mRNA inhibition | 19325750 |
SM2673 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Peptide nucleic acids Peptide nucleic acids |
21 21 |
Phosphate Phosphate |
56 percent target mRNA inhibition | 19325750 |
SM2688 |
UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU |
UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
21 6 * 20,21 |
Sugar Sugar |
2.75 (log-10 CVB-3 titre pfu/ml) | 20005874 |
SM2689 |
UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU |
UnLocked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
21 7 * 20,21 |
Sugar Sugar |
2.625 (log-10 CVB-3 titre pfu/ml) | 20005874 |
SM2690 |
UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU |
UnLocked nucleic acid Locked nucleic acid |
21 20,21 |
Sugar Sugar |
2.93 (log-10 CVB-3 titre pfu/ml) | 20005874 |
SM2694 |
UUCUCCGAACGUGUCACGUUUU ACGUGACACGUUCGGAGAAUUU |
UnLocked nucleic acid 0 |
21 0 |
Sugar 0 |
2.73 (log-10 CVB-3 titre pfu/ml) | 20005874 |
SM2714 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Pyrene modification 0 |
21 0 |
Sugar 0 |
71 percent target mRNA inhibition | 20485810 |
SM2715 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Anthracene 0 |
21 0 |
Sugar 0 |
75 percent target mRNA inhibition | 20485810 |
SM2716 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Naphthalene modification 0 |
21 0 |
Sugar 0 |
69 percent target mRNA inhibition | 20485810 |
SM2717 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Trifluoromethylbenzene 0 |
21 0 |
Sugar 0 |
74 percent target mRNA inhibition | 20485810 |
SM2718 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Fluorobenzene 0 |
21 0 |
Sugar 0 |
70 percent target mRNA inhibition | 20485810 |
SM2719 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Methyl 0 |
21 0 |
Sugar 0 |
70 percent target mRNA inhibition | 20485810 |
SM2749 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Pyrene modification 0 |
21 0 |
Sugar 0 |
80 percent target mRNA inhibition | 20485810 |
SM2750 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Anthracene 0 |
21 0 |
Sugar 0 |
77 percent target mRNA inhibition | 20485810 |
SM2751 |
UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT |
Naphthalene modification 0 |
21 0 |
Sugar 0 |
80 percent target mRNA inhibition | 20485810 |