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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 21 are 161
Results from 25 - 50

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0582	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	21 18,19 * 21	Sugar Sugar	28.9 percent target mRNA inhibition	19282453
SM0623	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Fluoro* 2-O-Methyl	21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	80.7 percent target mRNA inhibition	19282453
SM0627	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Fluoro* 2-O-Methyl	21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	81.3 percent target mRNA inhibition	19282453
SM0668	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	21 3,18	Sugar Sugar	58 percent target mRNA inhibition	19282453
SM0672	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	21 3,18	Sugar Sugar	54 percent target mRNA inhibition	19282453
SM0713	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	21 4,18	Sugar Sugar	28.9 percent target mRNA inhibition	19282453
SM0717	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	21 4,18	Sugar Sugar	43.5 percent target mRNA inhibition	19282453
SM0758	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	21 3,4,18	Sugar Sugar	88.9 percent target mRNA inhibition	19282453
SM0762	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	21 3,4,18	Sugar Sugar	93.5 percent target mRNA inhibition	19282453
SM0803	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	21 3,18	Sugar Sugar	82.6 percent target mRNA inhibition	19282453
SM0807	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	21 3,18	Sugar Sugar	84.8 percent target mRNA inhibition	19282453
SM0848	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	21 4,18	Sugar Sugar	79.8 percent target mRNA inhibition	19282453
SM0852	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	21 4,18	Sugar Sugar	78.4 percent target mRNA inhibition	19282453
SM0893	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	21 3,4,18	Sugar Sugar	89.3 percent target mRNA inhibition	19282453
SM0897	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	21 3,4,18	Sugar Sugar	89.4 percent target mRNA inhibition	19282453
SM0938	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	21 3,18	Sugar Sugar	79.9 percent target mRNA inhibition	19282453
SM0942	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	21 3,18	Sugar Sugar	80.4 percent target mRNA inhibition	19282453
SM0983	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	21 4,18	Sugar Sugar	79.6 percent target mRNA inhibition	19282453
SM0987	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	21 4,18	Sugar Sugar	80.8 percent target mRNA inhibition	19282453
SM1028	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	21 3,4,18	Sugar Sugar	75.6 percent target mRNA inhibition	19282453
SM1032	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	21 3,4,18	Sugar Sugar	76.8 percent target mRNA inhibition	19282453
SM1073	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Aminoethyl	21 20,21	Sugar Sugar	88.7 percent target mRNA inhibition	19282453
SM1077	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-Aminoethyl	21 20,21	Sugar Sugar	90.3 percent target mRNA inhibition	19282453
SM1118	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-Aminopropyl	21 1	Sugar Sugar	50.1 percent target mRNA inhibition	19282453
SM1122	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-Aminopropyl	21 1	Sugar Sugar	70.8 percent target mRNA inhibition	19282453



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