Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 21 are 161
Results from 50 - 75

« previous1234567next »

SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1163	GACGUAAACGGCCACAAGUUTU ACUUGTGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	89 percent target mRNA inhibition	19282453
SM1167	GACGUAAACGGCCACAAGUUUU ACUUGTGGCCGUUUACGUCGCU	UnLocked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	93.7 percent target mRNA inhibition	19282453
SM1207	GACGUAAACGGCCACAAGUTCU ACTUGTGGCCGUUTACGTCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid	21 3,6,14,18 * 20,21	Sugar Sugar	35.3 percent target mRNA inhibition	19282453
SM1208	GACGUAAACGGCCACAAGUUTU ACTUGTGGCCGUUTACGTCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid	21 3,6,14,18 * 20,21	Sugar Sugar	14.2 percent target mRNA inhibition	19282453
SM1212	GACGUAAACGGCCACAAGUUUU ACTUGTGGCCGUUTACGTCGCU	UnLocked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid	21 3,6,14,18 * 20,21	Sugar Sugar	28.5 percent target mRNA inhibition	19282453
SM1254	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Locked nucleic acid	21 20,21	Sugar Sugar	90.6 percent target mRNA inhibition	19282453
SM1258	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Locked nucleic acid	21 20,21	Sugar Sugar	91.3 percent target mRNA inhibition	19282453
SM1299	GACGUAAACGGCCACAAGUUTU ACTUGTGGCCGUUTACGTCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Locked nucleic acid	21 3,6,14,18,20,21	Sugar Sugar	56.7 percent target mRNA inhibition	19282453
SM1303	GACGUAAACGGCCACAAGUUUU ACTUGTGGCCGUUTACGTCGCU	UnLocked nucleic acid Locked nucleic acid	21 3,6,14,18,20,21	Sugar Sugar	57.1 percent target mRNA inhibition	19282453
SM1344	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	21 19,21	Sugar Sugar	85.9 percent target mRNA inhibition	19282453
SM1348	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	21 19,21	Sugar Sugar	87.7 percent target mRNA inhibition	19282453
SM1389	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid Alfa-L-Locked nucleic acid	21 21	Sugar Sugar	89.4 percent target mRNA inhibition	19282453
SM1393	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Alfa-L-Locked nucleic acid	21 21	Sugar Sugar	89.9 percent target mRNA inhibition	19282453
SM1434	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid 0	21 0	Sugar 0	89.5 percent target mRNA inhibition	19282453
SM1438	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 0	21 0	Sugar 0	89.1 percent target mRNA inhibition	19282453
SM1479	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCTTU	4-C-Hydroxymethyl Deoxyribonucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	21 20,21	Sugar Sugar	68.9 percent target mRNA inhibition	19282453
SM1483	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCTTU	UnLocked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	21 20,21	Sugar Sugar	76.9 percent target mRNA inhibition	19282453
SM1524	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGTU	4-C-Hydroxymethyl Deoxyribonucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	21 21	Sugar Sugar	79.6 percent target mRNA inhibition	19282453
SM1528	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGTU	UnLocked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	21 21	Sugar Sugar	87.5 percent target mRNA inhibition	19282453
SM1569	GACGUAAACGGCCACAAGUUTU ACUUGTGGCCGUUUACGUCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	46.7 percent target mRNA inhibition	19282453
SM1573	GACGUAAACGGCCACAAGUUUU ACUUGTGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 6 * 20,21	Sugar Sugar	48.1 percent target mRNA inhibition	19282453
SM1614	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGUCGC	4-C-Hydroxymethyl Deoxyribonucleic acid Locked nucleic acid	21 19,20	Sugar Sugar	86.1 percent target mRNA inhibition	19282453
SM1618	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid Locked nucleic acid	21 19,20	Sugar Sugar	86 percent target mRNA inhibition	19282453
SM1659	GACGUAAACGGCCACAAGUUTU ACUUGUGGCCGUUUACGTCGCU	4-C-Hydroxymethyl Deoxyribonucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 18 * 20,21	Sugar Sugar	70 percent target mRNA inhibition	19282453
SM1663	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGTCGCU	UnLocked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	21 18 * 20,21	Sugar Sugar	73.8 percent target mRNA inhibition	19282453



« previous1234567next »