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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 22,23 are 10
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2493
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2501
    UGGAAUGAACCACUGGAAUUUTT
    AAAUUCCAGUGGUUCAUUCCATT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM4233
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    0
    22,23
    0
    Sugar
    0
    90 percent target mRNA inhibition
    25233814
    SM4238
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    22,23
    22,23
    Sugar
    Sugar
    82 percent target mRNA inhibition
    25233814
    SM4239
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    22,23
    1,2
    Sugar
    Sugar
    74 percent target mRNA inhibition
    25233814
    SM4245
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    22,23
    1,2,22,23
    Sugar
    Sugar
    55 percent target mRNA inhibition
    25233814
    SM4252
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    0
    22,23
    0
    Sugar
    0
    91 percent target mRNA inhibition
    25233814
    SM4257
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    22,23
    22,23
    Sugar
    Sugar
    97 percent target mRNA inhibition
    25233814
    SM4258
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    22,23
    1,2
    Sugar
    Sugar
    98 percent target mRNA inhibition
    25233814
    SM4264
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    22,23
    1,2,22,23
    Sugar
    Sugar
    99 percent target mRNA inhibition
    25233814