Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 5,20 * 21 are 48
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0038
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-O-Methyl
    5,20 * 21
    2
    Sugar
    Sugar
    35 percent target mRNA inhibition
    19282453
    SM0084
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,20 * 21
    1 * 21
    Sugar
    Sugar
    64.9 percent target mRNA inhibition
    19282453
    SM0129
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    5,20 * 21
    1 * 18
    Sugar
    Sugar
    19.1 percent target mRNA inhibition
    19282453
    SM0174
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Altritol nucleic acid
    5,20 * 21
    1,2
    Sugar
    Sugar
    25.5 percent target mRNA inhibition
    19282453
    SM0219
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Altritol nucleic acid
    5,20 * 21
    20,21
    Sugar
    Sugar
    86.1 percent target mRNA inhibition
    19282453
    SM0264
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Altritol nucleic acid
    5,20 * 21
    5,8,11,14,17,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0309
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Altritol nucleic acid
    5,20 * 21
    3,6,14,18,20,21
    Sugar
    Sugar
    70.2 percent target mRNA inhibition
    19282453
    SM0354
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,20 * 21
    18,19,20 * 21
    Sugar
    Sugar
    78.1 percent target mRNA inhibition
    19282453
    SM0399
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,20 * 21
    2,18,19,20 * 21
    Sugar
    Sugar
    75.4 percent target mRNA inhibition
    19282453
    SM0444
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,20 * 21
    3,18,19,20 * 21
    Sugar
    Sugar
    69.5 percent target mRNA inhibition
    19282453
    SM0489
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,20 * 21
    2,9,18,19,20 * 21
    Sugar
    Sugar
    2.1 percent target mRNA inhibition
    19282453
    SM0534
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Aminoethoxymethyl* 2-Deoxy
    5,20 * 21
    18,19 * 21
    Sugar
    Sugar
    23.5 percent target mRNA inhibition
    19282453
    SM0579
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGT
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Aminopropoxymethyl* 2-Deoxy
    5,20 * 21
    18,19 * 21
    Sugar
    Sugar
    12.5 percent target mRNA inhibition
    19282453
    SM0624
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Fluoro* 2-O-Methyl
    5,20 * 21
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    Sugar
    Sugar
    26.3 percent target mRNA inhibition
    19282453
    SM0669
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    5,20 * 21
    3,18
    Sugar
    Sugar
    3 percent target mRNA inhibition
    19282453
    SM0714
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    5,20 * 21
    4,18
    Sugar
    Sugar
    9.3 percent target mRNA inhibition
    19282453
    SM0759
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid
    5,20 * 21
    3,4,18
    Sugar
    Sugar
    71.6 percent target mRNA inhibition
    19282453
    SM0804
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,20 * 21
    3,18
    Sugar
    Sugar
    44.6 percent target mRNA inhibition
    19282453
    SM0849
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,20 * 21
    4,18
    Sugar
    Sugar
    21.5 percent target mRNA inhibition
    19282453
    SM0894
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,20 * 21
    3,4,18
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0939
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,20 * 21
    3,18
    Sugar
    Sugar
    16.9 percent target mRNA inhibition
    19282453
    SM0984
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,20 * 21
    4,18
    Sugar
    Sugar
    20.3 percent target mRNA inhibition
    19282453
    SM1029
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,20 * 21
    3,4,18
    Sugar
    Sugar
    40.5 percent target mRNA inhibition
    19282453
    SM1074
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Aminoethyl
    5,20 * 21
    20,21
    Sugar
    Sugar
    86.9 percent target mRNA inhibition
    19282453
    SM1119
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Aminopropyl
    5,20 * 21
    1
    Sugar
    Sugar
    35.2 percent target mRNA inhibition
    19282453