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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 15919084 are 20
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4857
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    3,12,15,16
    0
    Sugar
    0
    96.3 percent target mRNA inhibition
    15919084
    SM4858
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,5,7,14,17
    0
    Sugar
    0
    93.6 percent target mRNA inhibition
    15919084
    SM4859
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,3,5,7,12,14,15,16,17
    0
    Sugar
    0
    92.9 percent target mRNA inhibition (IC-50 = 0.12 nM)
    15919084
    SM4860
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    60.3 percent target mRNA inhibition
    15919084
    SM4861
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,7,9,10,16
    0
    Sugar
    79.5 percent target mRNA inhibition (IC-50 = 1.65 nM)
    15919084
    SM4862
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    2,11,12,14,18
    0
    Sugar
    68.5 percent target mRNA inhibition (IC-50 = 2.09 nM)
    15919084
    SM4863
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,7,9,10,11,12,14,16,18
    0
    Sugar
    27.5 percent target mRNA inhibition
    15919084
    SM4864
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    16.6 percent target mRNA inhibition
    15919084
    SM4865
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6
    0
    Sugar
    0
    94 percent target mRNA inhibition
    15919084
    SM4866
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    14,15,16,17,18,19
    0
    Sugar
    0
    93.8 percent target mRNA inhibition
    15919084
    SM4867
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    7,8,9,10,11,12,13
    0
    Sugar
    0
    87.4 percent target mRNA inhibition (IC-50 = 0.31 nM)
    15919084
    SM4868
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    0
    91.5 percent target mRNA inhibition (IC-50 = 0.16 nM)
    15919084
    SM4869
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4,5,6
    0
    Sugar
    70.9 percent target mRNA inhibition (IC-50 = 2.62 nM)
    15919084
    SM4870
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    14,15,16,17,18,19
    0
    Sugar
    72.2 percent target mRNA inhibition (IC-50 = 1.98 nM)
    15919084
    SM4871
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    7,8,9,10,11,12,13
    0
    Sugar
    36.5 percent target mRNA inhibition
    15919084
    SM4872
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    22.8 percent target mRNA inhibition
    15919084
    SM4873
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    2-O-Methyl
    0
    1,2,3,4,5,6
    0
    Sugar
    0
    94.8 percent target mRNA inhibition
    15919084
    SM4874
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    2-O-Methyl
    0
    14,15,16,17,18,19
    0
    Sugar
    0
    94.2 percent target mRNA inhibition
    15919084
    SM4875
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    2-O-Methyl
    0
    1,2,3,4,5,6
    0
    Sugar
    10.3 percent target mRNA inhibition
    15919084
    SM4876
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    2-O-Methyl
    0
    14,15,16,17,18,19
    0
    Sugar
    30.8 percent target mRNA inhibition
    15919084