A database of experimentally validated
chemically modified siRNAs
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Modification in sense
Position in sense strand
Modification in antisense
Position in antisense
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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
By modification in sense strand
By modification position in sense strand
By modification in antisense strand
By modification position in antisense strand
Reference
Total number of Results for
16195704
are
1
Results from
0 - 25
SMDBid
siRNA (sense/antisense) 5'>3'
Modification (sense/antisense)
Position (sense/antisense)
Modified component (sense/antisense)
Efficacy (%)
Reference
SM3409
CUGAGUUUAAAAGGCACCCTT
TTGACUCAAAUUUUCCGUGGG
2-O-Methyl
2-O-Methyl* Cholesterol
20,21
1,2 * 1
Sugar
Sugar; Phosphate
IC-50 = 0.05 nM for target mRNA
16195704