SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4894 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
14,15,16,17,18,19 0 |
Sugar 0 |
93.8 percent target mRNA inhibition | 17924376 |
SM4895 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
16,17,18,19 0 |
Sugar 0 |
94.3 percent target mRNA inhibition | 17924376 |
SM4896 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
18,19 0 |
Sugar 0 |
95.4 percent target mRNA inhibition | 17924376 |
SM4897 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,5,6 0 |
Sugar 0 |
94 percent target mRNA inhibition | 17924376 |
SM4898 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4 0 |
Sugar 0 |
94.2 percent target mRNA inhibition | 17924376 |
SM4899 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2 0 |
Sugar 0 |
95.5 percent target mRNA inhibition | 17924376 |
SM4900 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,5,6,14,15,16,17,18,19 0 |
Sugar 0 |
91.5 percent target mRNA inhibition | 17924376 |
SM4901 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,3,4,16,17,18,19 0 |
Sugar 0 |
94.7 percent target mRNA inhibition | 17924376 |
SM4902 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 0 |
1,2,18,19 0 |
Sugar 0 |
95.3 percent target mRNA inhibition | 17924376 |
SM4903 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 1,2,3,4,5,6 |
0 Sugar |
70.9 percent target mRNA inhibition | 17924376 |
SM4904 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 1,2,3,4 |
0 Sugar |
76.7 percent target mRNA inhibition | 17924376 |
SM4905 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 1,2 |
0 Sugar |
95 percent target mRNA inhibition | 17924376 |
SM4906 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 14,15,16,17,18,19 |
0 Sugar |
72.2 percent target mRNA inhibition | 17924376 |
SM4907 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 16,17,18,19 |
0 Sugar |
85.6 percent target mRNA inhibition | 17924376 |
SM4908 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 18,19 |
0 Sugar |
90.2 percent target mRNA inhibition | 17924376 |
SM4909 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 1,2,3,4,5,6,14,15,16,17,18,19 |
0 Sugar |
22.8 percent target mRNA inhibition | 17924376 |
SM4910 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 1,2,3,4,16,17,18,19 |
0 Sugar |
20 percent target mRNA inhibition | 17924376 |
SM4911 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
0 4-Thioribose |
0 1,2,18,19 |
0 Sugar |
88.8 percent target mRNA inhibition | 17924376 |
SM4913 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
14,15,16,17,18,19 1,2,3,4,5,6 |
Sugar Sugar |
10.9 percent target mRNA inhibition | 17924376 |
SM4914 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
16,17,18,19 1,2,3,4 |
Sugar Sugar |
35.1 percent target mRNA inhibition | 17924376 |
SM4915 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
18,19 1,2 |
Sugar Sugar |
91.2 percent target mRNA inhibition | 17924376 |
SM4916 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
1,2,3,4,5,6 14,15,16,17,18,19 |
Sugar Sugar |
47.8 percent target mRNA inhibition | 17924376 |
SM4917 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
1,2,3,4 16,17,18,19 |
Sugar Sugar |
86.1 percent target mRNA inhibition | 17924376 |
SM4918 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
1,2 18,19 |
Sugar Sugar |
91.3 percent target mRNA inhibition | 17924376 |
SM4919 |
CGUACGCGGAAUACUUCGATT UCGAAGUAUUCCGCGUACGTT |
4-Thioribose 4-Thioribose |
1,2,3,4,5,6,14,15,16,17,18,19 1,2,3,4,5,6,14,15,16,17,18,19 |
Sugar Sugar |
0 percent target mRNA inhibition | 17924376 |