SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3796 |
UCUCGUAAGGACGAAACGATT UCGUUUCGUCCUUACGAGATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3800 |
GCUGUAACCUCGGAGAGUUTT AACUCUCCGAGGUUACAGCTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3804 |
CCUCGGAGAGUUCUACUCUTT AGAGUAGAACUCUCCGAGGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3808 |
GCAAGUGGCAAGAGGAUUATT UAAUCCUCUUGCCACUUGCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
55 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3812 |
AUGGGAGAAGUAGUCCCCCTT GGGGGACUACUUCUCCCAUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
71 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3816 |
AAGUAGUCCCCCUUGAAGATT UCUUCAAGGGGGACUACUUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
53 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3824 |
AGCGCUUAAAGGGCGAGAAGATT UCUUCUCGCCCUUUAAGCGCUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
49 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3836 |
AAGGACCUAGAGGAGUCACTT GUGACUCCUCUAGGUCCUUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
31 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3844 |
UUAAAGGGCGAGAAGACCGTT CGGUCUUCUCGCCCUUUAATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
67 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3852 |
CUAGAGGAUCUUGAAGACCTT GGUCUUCAAGAUCCUCUAGTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
61 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3864 |
CUCUGGCCUUUCUCUCUAGTT CUAGAGAGAAAGGCCAGAGTT |
2-O-Methyl 0 |
1,3,5,7,9,10,13,15,17,19 0 |
Sugar 0 |
24 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3866 |
CUCUGGCCUUUCUCUCUAGTT CUAGAGAGAAAGGCCAGAGTT |
2-O-Methyl 0 |
17 0 |
Sugar 0 |
47 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3868 |
GACAAGGGAAGGUUAGCCUTT AGGCUAACCUUCCCUUGUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3872 |
AGACUAAGCCCAAAAGGGCTT GCCCUUUUGGGCUUAGUCUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
26 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3884 |
GGGAGGUCUUAGAAAACACTT GUGUUUUCUAAGACCUCCCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
17 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3888 |
GGCUUAGUCACUCCUCUUCTT GAAGAGGAGUGACUAAGCCTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
23 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3912 |
UUCUAACCGGGCAGCUUCUTT AGAAGCUGCCCGGUUAGAATT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
61 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3948 |
UUACCCCGAUUCAGCCUCUTT AGAGGCUGAAUCGGGGUAATT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
67 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4002 |
UCUCCCACCCAAUGGAGAU AUCUCCAUUGGGUGGGAGATT |
2-O-Methyl 0 |
6,11 0 |
Sugar 0 |
81 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4006 |
AAACCAGGAAGGGGAAAUCTT GAUUUCCCCUUCCUGGUUUTT |
2-Deoxy-2-Fluoro 0 |
5,6 0 |
Sugar 0 |
64 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4008 |
GAAGGGGAAAUCUGUGGUUTT AACCACAGAUUUCCCCUUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
41 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4016 |
GAAACUGGUACUUUCCCCCTT GGGGGAAAGUACCAGUUUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
57 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4042 |
CCCUCCCCUGUCCCCGCUUTT AAGCGGGGACAGGGGAGGGTT |
2-Deoxy-2-Fluoro 0 |
9 0 |
Sugar 0 |
73 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4046 |
UUUGAUCAGCGGAGACUCGTT CGAGUCUCCGCUGAUCAAATT |
2-O-Methyl 0 |
4,7 0 |
Sugar 0 |
82 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM4058 |
AAACCCCUAGAGGGCAAGUTT ACUUGCCCUCUAGGGGUUUTT |
2-Deoxy-2-Fluoro 0 |
8,15 0 |
Sugar 0 |
83 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |