SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3705 |
AGCCUCCAAACUCCUAGCUTT AGCUAGGAGUUUGGAGGCUTT |
2-Deoxy-2-Fluoro 0 |
7,15 0 |
Sugar 0 |
32 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3708 |
UCCUAGCUGUCUUGUCCCUTT AGGGACAAGACAGCUAGGATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
27 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3712 |
AUACUUGGCGGGCUCUUUCTT GAAAGAGCCCGCCAAGUAUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
19 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3714 |
AUACUUGGCGGGCUCUUUCTT GAAAGAGCCCGCCAAGUAUTT |
2-O-Methyl 0 |
2 0 |
Sugar 0 |
48 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3716 |
GGGGCUCUUCUACAUUCCCTT GGGAAUGUAGAAGAGCCCCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3720 |
GAGUAUUUCCGCUGGAACUTT AGUUCCAGCGGAAAUACUCTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
21 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3724 |
GCUGAGGAAAGGGACAUCUTT AGAUGUCCCUUUCCUCAGCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
61 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3728 |
GUACUCUGAUGAGGAAGAGTT CUCUUCCUCAUCAGAGUACTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
18 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3730 |
GUACUCUGAUGAGGAAGAGTT CUCUUCCUCAUCAGAGUACTT |
2-O-Methyl 0 |
2 0 |
Sugar 0 |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3732 |
GGCCAAAGUAAUCGUGGUUTT AACCACGAUUACUUUGGCCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
37 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3736 |
GUCUAUGCCAAGAAGGGAGTT CUCCCUUCUUGGCAUAGACTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
24 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3740 |
UCUACACCGCGCCCCCCUCTT GAGGGGGGCGCGGUGUAGATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
39 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3744 |
CGCCCCCCUCAAGCUACCGTT CGGUAGCUUGAGGGGGGCGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
44 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3748 |
GCUACCGCAACCACGAGCUTT AGCUCGUGGUUGCGGUAGCTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
21 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3752 |
CUCCUUCAUUCCAGCCUAUTT AUAGGCUGGAAUGAAGGAGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3756 |
AGAAAAGCAGCGAUACGCUTT AGCGUAUCGCUGCUUUUCUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3758 |
AGAAAAGCAGCGAUACGCUTT AGCGUAUCGCUGCUUUUCUTT |
2-O-Methyl 0 |
14 0 |
Sugar 0 |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3760 |
GGAGCUAGACGGGUACGAGTT CUCGUACCCGUCUAGCUCCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
75 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3764 |
CGGGUACGAGCCGGAACCUTT AGGUUCCGGCUCGUACCCGTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
61 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3768 |
ACGGCUCGCUACCCUCGACTT GUCGAGGGUAGCGAGCCGUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
72 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3770 |
ACGGCUCGCUACCCUCGACTT GUCGAGGGUAGCGAGCCGUTT |
2-Deoxy-2-Fluoro 0 |
11 0 |
Sugar 0 |
83 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3774 |
AGAGGACCUAGAAGGCGGCTT GCCGCCUUCUAGGUCCUCUTT |
2-O-Methyl 0 |
10 0 |
Sugar 0 |
92 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3784 |
AGUAAUCCGGACUCAACUCTT GAGUUGAGUCCGGAUUACUTT |
2-Deoxy-2-Fluoro 0 |
3,6,7,8,12,13,14,17,18,19 0 |
Sugar 0 |
59 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3788 |
GAGGAAGAUGAGUUGUACCTT GGUACAACUCAUCUUCCUCTT |
2-O-Methyl 0 |
1,2,3,4,5,6,7,8,10,11,12,15,17 0 |
Sugar 0 |
70 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3792 |
AGAUGUUCUCGUAAGGACGTT CGUCCUUACGAGAACAUCUTT |
2-O-Methyl 0 |
2,4,6,7,8,9,10,12,15,18 0 |
Sugar 0 |
53 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |