SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3616 |
CGAGUGUCUAACGGGAGCCTT GGCUCCCGUUAGACACUCGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
25 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3620 |
GACCACGAAGAGUUAACCCTT GGGUUAACUCUUCGUGGUCTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3624 |
AGUUAACCCGGGACUUGGATT UCCAAGUCCCGGGUUAACUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
65 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3628 |
AUCACAAACCCCUAGAGGGTT CCCUCUAGGGGUUUGUGAUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
9 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3632 |
AAACCCCUAGAGGGCAAGUTT ACUUGCCCUCUAGGGGUUUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
62 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3636 |
UCCGGCUAACUCUGAGGACTT GUCCUCAGAGUUAGCCGGATT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
41 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3640 |
CGACGAUUCUUCUACUCAATT UUGAGUAGAAGAAUCGUCGTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
56 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3644 |
UAAACUUUGGGGAAGGGAGTT CUCCCUUCCCCAAAGUUUATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3648 |
AGCGGGGUAUGAAGAGCUUTT AAGCUCUUCAUACCCCGCUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
75 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3652 |
CUCCCCAGUCUCUCUUAAATT UUUAAGAGAGACUGGGGAGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3656 |
GAAUAACCUGAACGUCACCTT GGUGACGUUCAGGUUAUUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
17 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3660 |
ACGUCACCGAGGAGAAGUATT UACUUCUCCUCGGUGACGUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
36 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3662 |
ACGUCACCGAGGAGAAGUATT UACUUCUCCUCGGUGACGUTT |
2-O-Methyl 0 |
18 0 |
Sugar 0 |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3664 |
AGAAGUACCAGGAGGCGUUTT AACGCCUCCUGGUACUUCUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
24 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3668 |
AGCCCAGAUAGCUCUUCAGTT CUGAAGAGCUAUCUGGGCUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
35 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3672 |
AAACCUCAGCCCUAACGGUTT ACCGUUAGGGCUGAGGUUUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3676 |
UUAAGGAGAAGCUGACGGCTT GCCGUCAGCUUCUCCUUAATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
24 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3680 |
AAGGAACGGGGACACUUACTT GUAAGUGUCCCCGUUCCUUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
12 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3684 |
GGAGCACGCUUACUACCUUTT AAGGUAGUAAGCGUGCUCCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3688 |
GGCGGGCUCUUUCCUAUUCTT GAAUAGGAAAGAGCCCGCCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3692 |
CCGAGAGCUCUCCUACCUUTT AAGGUAGGAGAGCUCUCGGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
34 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3696 |
CUCUCCUACCUUCUCCUCUTT AGAGGAGAAGGUAGGAGAGTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
69 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3698 |
CUCUCCUACCUUCUCCUCUTT AGAGGAGAAGGUAGGAGAGTT |
2-Deoxy-2-Fluoro 0 |
8 0 |
Sugar 0 |
78 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3700 |
CUACCUUCUCCUCUUCUCCTT GGAGAAGAGGAGAAGGUAGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
27 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3704 |
AGCCUCCAAACUCCUAGCUTT AGCUAGGAGUUUGGAGGCUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
16 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |