SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3509 |
GGACUACUAACCUCCAGUUTT AACUGGAGGUUAGUAGUCCTT |
2-O-Methyl 0 |
1,2,3,6,9,10,16,17 0 |
Sugar 0 |
65 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3512 |
GAAACUGGUACUUUCCCCCTT GGGGGAAAGUACCAGUUUCTT |
2-Deoxy-2-Fluoro 0 |
2,5,6,9,10,11,12,13,14,15,16,17,18,19 0 |
Sugar 0 |
60 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3517 |
UUUCCCCCAGGUAACGAUUTT AAUCGUUACCUGGGGGAAATT |
2-Deoxy-2-Fluoro 0 |
9,10,11,13,14,15,16 0 |
Sugar 0 |
78 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3521 |
CCCCAGGUAACGAUUUUCUTT AGAAAAUCGUUACCUGGGGTT |
2-O-Methyl 0 |
5,6,7,8,9,10,11 0 |
Sugar 0 |
79 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3525 |
GGGAAACUGAAAGGCUAUGTT CAUAGCCUUUCAGUUUCCCTT |
2-Deoxy-2-Fluoro 0 |
7,8,15,16,18 0 |
Sugar 0 |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3526 |
GGGAAACUGAAAGGCUAUGTT CAUAGCCUUUCAGUUUCCCTT |
2-Deoxy-2-Fluoro 0 |
16 0 |
Sugar 0 |
50 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3528 |
GCGAGCAGAGAAUCUACCUTT AGGUAGAUUCUCUGCUCGCTT |
2-O-Methyl 0 |
1,3,4,5,7,8,9,10,11,12,16 0 |
Sugar 0 |
65 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3533 |
GCAGAGAAUCUACCUUUCCTT GGAAAGGUAGAUUCUCUGCTT |
2-O-Methyl 0 |
1,3,4,5,6,7,8,12 0 |
Sugar 0 |
65 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3536 |
ACCUUUCCACUUCUAAGCCTT GGCUUAGAAGUGGAAAGGUTT |
2-O-Methyl 0 |
2,3,4,5,6,7,8,10,11,12,13,14,18,19 0 |
Sugar 0 |
75 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3542 |
CUAAGCCUGUUUCUUCCUCTT GAGGAAGAAACAGGCUUAGTT |
2-Deoxy-2-Fluoro 0 |
2 0 |
Sugar 0 |
82 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3545 |
GAAGAUAGGAAGGGGCUUCTT GAAGCCCCUUCCUAUCUUCTT |
2-Deoxy-2-Fluoro 0 |
6,16,17,18,19 0 |
Sugar 0 |
45 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3548 |
AAUAAGCAGCUCGCGCUCCTT GGAGCGCGAGCUGCUUAUUTT |
2-O-Methyl 0 |
1,2,4,5,6,8,9,13,15 0 |
Sugar 0 |
64 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3556 |
AACAGUCCUUAGCUACGCUTT AGCGUAGCUAAGGACUGUUTT |
2-O-Methyl 0 |
1,3,5,7,9,12,14,17 0 |
Sugar 0 |
35 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3572 |
AGUCCCUGGAGCCUUAAACTT GUUUAAGGCUCCAGGGACUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,17,19 0 |
Sugar 0 |
68 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3576 |
AGCCACAUUUCUAGGAGAUTT AUCUCCUAGAAAUGUGGCUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
19 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3580 |
GAUUCCAAACCCCACUAUCTT GAUAGUGGGGUUUGGAAUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
54 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3581 |
GAUUCCAAACCCCACUAUCTT GAUAGUGGGGUUUGGAAUCTT |
2-O-Methyl 0 |
6,16 0 |
Sugar 0 |
67 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3584 |
GAUACUUCUGGUUCCCUCCTT GGAGGGAACCAGAAGUAUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
45 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3588 |
AGAGAAGGGCGUCUCUACATT UGUAGAGACGCCCUUCUCUTT |
2-Deoxy-2-Fluoro 0 |
1,4,6,8,9,12,16,18 0 |
Sugar 0 |
75 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3592 |
AGUUUCUAGGGCCGUGGCCTT GGCCACGGCCCUAGAAACUTT |
2-Deoxy-2-Fluoro 0 |
1,3,5,7,9,11,12,14,17 0 |
Sugar 0 |
75 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3596 |
GAAGAGUUAACCCGGGACUTT AGUCCCGGGUUAACUCUUCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17 0 |
Sugar 0 |
17 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3600 |
CCGCCCGGCGGCGCCUUUATT UAAAGGCGCCGCCGGGCGGTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
49 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3604 |
ACCGACGAUUCUUCUACUCTT GAGUAGAAGAAUCGUCGGUTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
42 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3608 |
GGUAGAAUAGGUUUUCCCCTT GGGGAAAACCUAUUCUACCTT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
11 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3612 |
UCCCUUCCACCGCCAUAUUTT AAUAUGGCGGUGGAAGGGATT |
2-O-Methyl 0 |
1,3,5,7,9,11,13,15,17,19 0 |
Sugar 0 |
11 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |