SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4536 |
GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG |
2-Deoxyribonucleotide 1-Aminohexane |
24,25 27 |
Sugar Phosphate |
53 percent target mRNA inhibition | 22236254 |
SM4537 |
GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG |
2-Deoxyribonucleotide* 1-Aminohexane 1-Aminohexane |
24,25 * 25 27 |
Sugar; Phosphate Phosphate |
45 percent target mRNA inhibition | 22236254 |
SM4538 |
GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG |
2-Deoxyribonucleotide 1-Aminohexane |
24,25 1 |
Sugar Phosphate |
78 percent target mRNA inhibition | 22236254 |
SM4539 |
GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG |
2-Deoxyribonucleotide* 1-Aminohexane 1-Aminohexane |
24,25 * 25 1 |
Sugar; Phosphate Phosphate |
45 percent target mRNA inhibition | 22236254 |
SM4541 |
GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG |
1-Aminohexane* 2-Deoxyribonucleotide 1-Aminohexane |
1 * 24,25 27 |
Phosphate; Sugar Phosphate |
45 percent target mRNA inhibition | 22236254 |
SM4542 |
GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG |
1-Aminohexane* 2-Deoxyribonucleotide 1-Aminohexane |
1 * 24,25 1 |
Phosphate; Sugar Phosphate |
56 percent target mRNA inhibition | 22236254 |
SM4543 |
GGCCUUUCACUACUCCUACGAGCAC GUGCUCGUAGGAGUAGUGAAAGGCCAG |
1-Aminohexane* 2-Deoxyribonucleotide* N-hexylhexadecanamide 1-Aminohexane |
1 * 24,25 * 25 1 |
Phosphate; Sugar Phosphate |
82 percent target mRNA inhibition | 22236254 |