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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Aminopropyl are 45
    Results from 25 - 50
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1107
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,9,13,15,20,21
    1
    Sugar
    Sugar
    53.9 percent target mRNA inhibition
    19282453
    SM1108
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-Aminopropyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    1
    Sugar
    Sugar
    15.2 percent target mRNA inhibition
    19282453
    SM1109
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-Aminopropyl
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    1
    Sugar
    Sugar
    28.4 percent target mRNA inhibition
    19282453
    SM1110
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-Aminopropyl
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    1
    Sugar
    Sugar
    16.8 percent target mRNA inhibition
    19282453
    SM1111
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    5,20,21
    1
    Sugar
    Sugar
    30 percent target mRNA inhibition
    19282453
    SM1112
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,5,7,9,20,21
    1
    Sugar
    Sugar
    8.9 percent target mRNA inhibition
    19282453
    SM1113
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,9,13,15,20,21
    1
    Sugar
    Sugar
    8.8 percent target mRNA inhibition
    19282453
    SM1114
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-Aminopropyl
    20,21
    1
    Sugar
    Sugar
    73.8 percent target mRNA inhibition
    19282453
    SM1115
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-Aminopropyl
    3,5,9,13,20,21
    1
    Sugar
    Sugar
    50.1 percent target mRNA inhibition
    19282453
    SM1116
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-Aminopropyl
    20,21
    1
    Sugar
    Sugar
    56.9 percent target mRNA inhibition
    19282453
    SM1117
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-Aminopropyl
    3,9,15,20,21
    1
    Sugar
    Sugar
    46.3 percent target mRNA inhibition
    19282453
    SM1118
    GACGUAAACGGCCACAAGUUTU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-Aminopropyl
    21
    1
    Sugar
    Sugar
    50.1 percent target mRNA inhibition
    19282453
    SM1119
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-Aminopropyl
    5,20 * 21
    1
    Sugar
    Sugar
    35.2 percent target mRNA inhibition
    19282453
    SM1120
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid* Locked nucleic acid
    2-Aminopropyl
    5 * 20,21
    1
    Sugar
    Sugar
    17.5 percent target mRNA inhibition
    19282453
    SM1121
    GACGUAAACCGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid* Locked nucleic acid
    2-Aminopropyl
    10 * 21,22
    1
    Sugar
    Sugar
    8.3 percent target mRNA inhibition
    19282453
    SM1122
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    2-Aminopropyl
    21
    1
    Sugar
    Sugar
    70.8 percent target mRNA inhibition
    19282453
    SM1123
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    2-Aminopropyl
    5,21
    1
    Sugar
    Sugar
    38 percent target mRNA inhibition
    19282453
    SM1124
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,8,13,15,20,21
    1
    Sugar
    Sugar
    12.8 percent target mRNA inhibition
    19282453
    SM1125
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    20,21
    1
    Sugar
    Sugar
    58.3 percent target mRNA inhibition
    19282453
    SM1126
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    2-Aminopropyl
    0
    1
    0
    Sugar
    55.1 percent target mRNA inhibition
    19282453