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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxyribonucleotide* Inverted thymidine are 8
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4464
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    65 percent target mRNA inhibition
    21985606
    SM4465
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    Palmitic acid* 2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    1 * 20 * 21
    20 * 21
    Phosphate; Sugar; Sugar
    Sugar
    88 percent target mRNA inhibition
    21985606
    SM4470
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    55 percent target mRNA inhibition
    21985606
    SM4471
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    1 * 20 * 21
    20 * 21
    Phosphate; Sugar; Sugar
    Sugar
    85 percent target mRNA inhibition
    21985606
    SM4476
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    12 percent target mRNA inhibition
    21985606
    SM4477
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    1 * 20 * 21
    20 * 21
    Phosphate; Sugar; Sugar
    Sugar
    30 percent target mRNA inhibition
    21985606
    SM4482
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606
    SM4483
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    1 * 20 * 21
    20 * 21
    Phosphate; Sugar; Sugar
    Sugar
    4 percent target mRNA inhibition
    21985606