SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4960 |
CCAGUAAGGCUUCUCUUAAUU UUAAGAGAAGCCUUACUGGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
96.82 percent target mRNA inhibition | 22253019 |
SM4970 |
CCAGUAAGGCUUCUCUUAAUU UUAAGAGAAGCCUUACUGGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
96.02 percent target mRNA inhibition | 22253019 |
SM4974 |
CCAGUAAGGCUUCUCUUAAUU UUAAGAGAAGCCUUACUGGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19,20,21 |
Base; Sugar; Sugar Sugar |
96.84 percent target mRNA inhibition | 22253019 |
SM5000 |
CACAAUGCAUUUAGAUCAAUU UUGAUCUAAAUGCAUUGUGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
95.54 percent target mRNA inhibition | 22253019 |
SM5004 |
CACAAUGCAUUUAGAUCAAUU UUGAUCUAAAUGCAUUGUGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19,20,21 |
Base; Sugar; Sugar Sugar |
74.3 percent target mRNA inhibition | 22253019 |
SM5030 |
CUUUAACAAUUCCUGAAAUUU AUUUCAGGAAUUGUUAAAGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
97.3 percent target mRNA inhibition | 22253019 |
SM5060 |
UCAUCACACUGAAUACCAAUU UUGGUAUUCAGUGUGAUGAUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
91.93 percent target mRNA inhibition | 22253019 |
SM5064 |
UCAUCACACUGAAUACCAAUU UUGGUAUUCAGUGUGAUGAUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19,20,21 |
Base; Sugar; Sugar Sugar |
93.59 percent target mRNA inhibition | 22253019 |
SM5090 |
ACAACAGACUUUAAUGUAAUU UUACAUUAAAGUCUGUUGUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
91.35 percent target mRNA inhibition | 22253019 |
SM5094 |
ACAACAGACUUUAAUGUAAUU UUACAUUAAAGUCUGUUGUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18,20,21 |
Base; Sugar; Sugar Sugar |
94.37 percent target mRNA inhibition | 22253019 |
SM5120 |
AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
95.96 percent target mRNA inhibition | 22253019 |
SM5124 |
AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,6,7,8,9,11,12,14,17,18,19* 5,10,13,15,16,20,21 |
Base; Sugar; Sugar Sugar |
95.72 percent target mRNA inhibition | 22253019 |
SM5140 |
CCAGUAAGGCUUCUCUUAAUU UUAAGAGAAGCCUUACUGGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
97.96 percent target mRNA inhibition | 22253019 |
SM5150 |
CCAGUAAGGCUUCUCUUAAUU UUAAGAGAAGCCUUACUGGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
98.7 percent target mRNA inhibition | 22253019 |
SM5154 |
CCAGUAAGGCUUCUCUUAAUU UUAAGAGAAGCCUUACUGGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,11,12,13,14,16,17 * 3,4,5,6,7,8,9,10,15,18,19,20,21 |
Base; Sugar; Sugar Sugar |
97.68 percent target mRNA inhibition | 22253019 |
SM5180 |
CACAAUGCAUUUAGAUCAAUU UUGAUCUAAAUGCAUUGUGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
97.82 percent target mRNA inhibition | 22253019 |
SM5184 |
CACAAUGCAUUUAGAUCAAUU UUGAUCUAAAUGCAUUGUGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,5,6,7,11,13,15,16,18 * 3,4,8,9,10,12,14,17,19,20,21 |
Base; Sugar; Sugar Sugar |
73.77 percent target mRNA inhibition | 22253019 |
SM5210 |
CUUUAACAAUUCCUGAAAUUU AUUUCAGGAAUUGUUAAAGUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
95.9 percent target mRNA inhibition | 22253019 |
SM5240 |
UCAUCACACUGAAUACCAAUU UUGGUAUUCAGUGUGAUGAUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
92.48 percent target mRNA inhibition | 22253019 |
SM5244 |
UCAUCACACUGAAUACCAAUU UUGGUAUUCAGUGUGAUGAUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,5,7,8,9,12,14,17 * 3,4,6,10,11,13,15,16,18,19,20,21 |
Base; Sugar; Sugar Sugar |
89.04 percent target mRNA inhibition | 22253019 |
SM5270 |
ACAACAGACUUUAAUGUAAUU UUACAUUAAAGUCUGUUGUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
88.41 percent target mRNA inhibition | 22253019 |
SM5274 |
ACAACAGACUUUAAUGUAAUU UUACAUUAAAGUCUGUUGUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,4,6,7,12,13,14,16,17,19 * 3,5,8,9,10,11,15,18,20,21 |
Base; Sugar; Sugar Sugar |
92.98 percent target mRNA inhibition | 22253019 |
SM5300 |
AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 |
Base; Sugar; Sugar Sugar |
93.42 percent target mRNA inhibition | 22253019 |
SM5304 |
AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU |
Inverted abasic* 2-Deoxy* 2-Methoxy 2-Fluoro* 2-Methoxy |
1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21 1,2,3,4,6,7,8,9,11,12,14,17,18,19* 5,10,13,15,16,20,21 |
Base; Sugar; Sugar Sugar |
93.28 percent target mRNA inhibition | 22253019 |