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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Methoxyribose* DeoxyThymidine are 2
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4844
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    2-Methoxyribose* DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    13,15 * 23,24
    Sugar
    Sugar
    27 percent target mRNA inhibition
    23344237
    SM4853
    GTCATCACACUGAATACCAAUUTT
    AAUUGGUAUUCAGUGUGAUGACTT
    2,4-bridged nucleic acid* Phosphorothioate* DeoxyThymidine* Cholesterol
    2-Methoxyribose* DeoxyThymidine
    1,2,5,15,18 * 3,4,6,7,16,17,19,20,21,22 * 23,24 * 24
    13,15 * 23,24
    Sugar
    Sugar
    73 percent target mRNA inhibition
    23344237