| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM0317 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
Hexitol nucleic acid* 2-Deoxy |
18
18,19,20 * 21 |
Sugar
Sugar |
87.5 percent target mRNA inhibition | 19282453 |
| SM0318 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Guanidinoethyl
Hexitol nucleic acid* 2-Deoxy |
18
18,19,20 * 21 |
Sugar
Sugar |
84.8 percent target mRNA inhibition | 19282453 |
| SM0319 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid
Hexitol nucleic acid* 2-Deoxy |
2,8,14,17
18,19,20 * 21 |
Sugar
Sugar |
63.5 percent target mRNA inhibition | 19282453 |
| SM0320 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid
Hexitol nucleic acid* 2-Deoxy |
5,8,14,17,22
18,19,20 * 21 |
Sugar
Sugar |
0 percent target mRNA inhibition | 19282453 |
| SM0321 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
1,2 * 22
18,19,20 * 21 |
Sugar
Sugar |
85.4 percent target mRNA inhibition | 19282453 |
| SM0322 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
18,19 * 22
18,19,20 * 21 |
Sugar
Sugar |
84.2 percent target mRNA inhibition | 19282453 |
| SM0323 |
GACGUAAACGGCCACAAGUUCT
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
5,8,11,14,17 * 22
18,19,20 * 21 |
Sugar
Sugar |
19.8 percent target mRNA inhibition | 19282453 |
| SM0324 |
GACGUAAACGGCCACAAGUUCU
ACUUGUGGCCGUUUACGUCGT |
Altritol nucleic acid
Hexitol nucleic acid* 2-Deoxy |
20,21
18,19,20 * 21 |
Sugar
Sugar |
80.3 percent target mRNA inhibition | 19282453 |
| SM0325 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid
Hexitol nucleic acid* 2-Deoxy |
19,20
18,19,20 * 21 |
Sugar
Sugar |
80.4 percent target mRNA inhibition | 19282453 |
| SM0326 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
1,2,3,18,19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
84.6 percent target mRNA inhibition | 19282453 |
| SM0327 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
5,8,11,14 * 21
18,19,20 * 21 |
Sugar
Sugar |
48.7 percent target mRNA inhibition | 19282453 |
| SM0328 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
Hexitol nucleic acid* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
5,8,11,14,19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
74.2 percent target mRNA inhibition | 19282453 |
| SM0329 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
86.3 percent target mRNA inhibition | 19282453 |
| SM0330 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
3,5,9,19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
81 percent target mRNA inhibition | 19282453 |
| SM0331 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
84.6 percent target mRNA inhibition | 19282453 |
| SM0332 |
GACGUAAACGGCCACAAGUUT
ACUUGUGGCCGUUUACGUCGT |
2-Aminopropoxymethyl* 2-Deoxy
Hexitol nucleic acid* 2-Deoxy |
3,5,9,19,20 * 21
18,19,20 * 21 |
Sugar
Sugar |
73.3 percent target mRNA inhibition | 19282453 |
| SM0333 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Oxetane-Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
16,18
18,19,20 * 21 |
Sugar
Sugar |
86 percent target mRNA inhibition | 19282453 |
| SM0334 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
Oxetane-Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
2,4
18,19,20 * 21 |
Sugar
Sugar |
85.7 percent target mRNA inhibition | 19282453 |
| SM0335 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Fluoro* 2-O-Methyl
Hexitol nucleic acid* 2-Deoxy |
1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
18,19,20 * 21 |
Sugar
Sugar |
84.8 percent target mRNA inhibition | 19282453 |
| SM0336 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
Hexitol nucleic acid* 2-Deoxy |
20
18,19,20 * 21 |
Sugar
Sugar |
85.9 percent target mRNA inhibition | 19282453 |
| SM0337 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
Hexitol nucleic acid* 2-Deoxy |
19
18,19,20 * 21 |
Sugar
Sugar |
85.4 percent target mRNA inhibition | 19282453 |
| SM0338 |
GACGUAAACGGCCACAAGUUC
ACUUGUGGCCGUUUACGUCGT |
2-Aminoethyl
Hexitol nucleic acid* 2-Deoxy |
5,19,20
18,19,20 * 21 |
Sugar
Sugar |
83.4 percent target mRNA inhibition | 19282453 |
| SM0339 |
GACGUAAACGGCCACAAGUTCU
ACUUGUGGCCGUUUACGUCGT |
Locked nucleic acid
Hexitol nucleic acid* 2-Deoxy |
3,9,15,20,21
18,19,20 * 21 |
Sugar
Sugar |
85.2 percent target mRNA inhibition | 19282453 |
| SM0340 |
GACGUAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
Hexitol nucleic acid* 2-Deoxy |
19,20
18,19,20 * 21 |
Sugar
Sugar |
81.4 percent target mRNA inhibition | 19282453 |
| SM0341 |
GACGTAAACGGCCACAAGTTC
ACUUGUGGCCGUUUACGUCGT |
4-C-Hydroxymethyl Deoxyribonucleic acid
Hexitol nucleic acid* 2-Deoxy |
5,19,20
18,19,20 * 21 |
Sugar
Sugar |
84.8 percent target mRNA inhibition | 19282453 |