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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
- By modification in sense strand
- By modification position in sense strand
- By modification in antisense strand
- By modification position in antisense strand
- Reference
Total number of Results for Phosphorothioate* Phosphodiester are 7
Results from 0 - 25
| SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
|---|
| SM3430 |
GGAGAUCAACAUUUUCAAA
UUUGAAAAUGUUGAUCUCC |
0
Phosphorothioate* Phosphodiester |
0
3,9,12,17,18,19 * 3,9,12,17,18 |
0
Sugar |
IC-50 = 5580 nM for target mRNA | US8394947, EP1765074B1 |
| SM3431 |
AAGUAAGGACCAGAGACAAA
UUUGUCUCUGGUCCUUACUU |
0
Phosphorothioate* Phosphodiester |
0
18,19,20 * 18,19 |
0
Sugar |
IC-50 = 22.046 nM for target mRNA | US8394947, EP1765074B1 |
| SM3432 |
AAGUAAGGACCAGAGACAAA
UUUGUCUCUGGUCCUUACUU |
0
Phosphorothioate* Phosphodiester |
0
16,18,19,20 * 16,18,19 |
0
Sugar |
IC-50 = 491 nM for target mRNA | US8394947, EP1765074B1 |
| SM3434 |
AAGUAAGGACCAGAGACAAA
UUUGUCUCUGGUCCUUACUU |
0
Phosphorothioate* Phosphodiester |
0
13,14,15 * 13,14,15 |
0
Sugar |
IC-50 = 273 nM for target mRNA | US8394947, EP1765074B1 |
| SM3435 |
AAGUAAGGACCAGAGACAAA
UUUGUCUCUGGUCCUUACUU |
0
Phosphorothioate* Phosphodiester |
0
12,13,14 * 12,13,14 |
0
Sugar |
IC-50 = 363 nM for target mRNA | US8394947, EP1765074B1 |
| SM3436 |
AAGUAAGGACCAGAGACAAA
UUUGUCUCUGGUCCUUACUU |
0
Phosphorothioate* Phosphodiester |
0
7,8,9 * 7,8,9 |
0
Sugar |
IC-50 = 131 nM for target mRNA | US8394947, EP1765074B1 |
| SM3437 |
AAGUAAGGACCAGAGACAAA
UUUGUCUCUGGUCCUUACUU |
0
Phosphorothioate* Phosphodiester |
0
1,2,3 * 1,2,3 |
0
Sugar |
IC-50 = 428 nM for target mRNA | US8394947, EP1765074B1 |