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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Triazole-linked nucleic acid are 15
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4546	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	1 * 20,21 20	Sugar; Backbone Backbone	51 percent target mRNA inhibition	22260772
SM4551	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	38 percent target mRNA inhibition	22260772
SM4554	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	76 percent target mRNA inhibition	22260772
SM4556	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	43 percent target mRNA inhibition	22260772
SM4558	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine Triazole-linked nucleic acid	20,21 20	Sugar Backbone	45 percent target mRNA inhibition	22260772
SM4561	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	1 * 20,21 20	Sugar; Backbone Backbone	58 percent target mRNA inhibition	22260772
SM4566	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	93 percent target mRNA inhibition	22260772
SM4569	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4571	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	81 percent target mRNA inhibition	22260772
SM4573	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine Triazole-linked nucleic acid	20,21 20	Sugar Backbone	89 percent target mRNA inhibition	22260772
SM4576	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	1 * 20,21 20	Sugar; Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4581	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid* 2-Deoxythymidine Triazole-linked nucleic acid	14 * 20,21 20	Sugar; Backbone Backbone	97 percent target mRNA inhibition	22260772
SM4584	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4586	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	85 percent target mRNA inhibition	22260772
SM4588	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine Triazole-linked nucleic acid	20,21 20	Sugar Backbone	98 percent target mRNA inhibition	22260772