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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Unlocked nucleic acid * Locked nucleic acid are 4
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2913
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2921
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2929
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2937
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    Unlocked nucleic acid * Locked nucleic acid
    21
    6 * 20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525