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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 are 85
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1082
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    18
    1
    Sugar
    Sugar
    41 percent target mRNA inhibition
    19282453
    SM1083
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-Aminopropyl
    18
    1
    Sugar
    Sugar
    55.3 percent target mRNA inhibition
    19282453
    SM1084
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminopropyl
    2,8,14,17
    1
    Sugar
    Sugar
    59.3 percent target mRNA inhibition
    19282453
    SM1085
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminopropyl
    5,8,14,17,22
    1
    Sugar
    Sugar
    38.6 percent target mRNA inhibition
    19282453
    SM1086
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-Aminopropyl
    1,2 * 22
    1
    Sugar
    Sugar
    49.2 percent target mRNA inhibition
    19282453
    SM1087
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-Aminopropyl
    18,19 * 22
    1
    Sugar
    Sugar
    46.6 percent target mRNA inhibition
    19282453
    SM1088
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-Aminopropyl
    5,8,11,14,17 * 22
    1
    Sugar
    Sugar
    31.7 percent target mRNA inhibition
    19282453
    SM1089
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    2-Aminopropyl
    20,21
    1
    Sugar
    Sugar
    40.3 percent target mRNA inhibition
    19282453
    SM1090
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-Aminopropyl
    19,20
    1
    Sugar
    Sugar
    55.6 percent target mRNA inhibition
    19282453
    SM1091
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-Aminopropyl
    1,2,3,18,19,20 * 21
    1
    Sugar
    Sugar
    60.4 percent target mRNA inhibition
    19282453
    SM1092
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-Aminopropyl
    5,8,11,14 * 21
    1
    Sugar
    Sugar
    48.5 percent target mRNA inhibition
    19282453
    SM1093
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-Aminopropyl
    5,8,11,14,19,20 * 21
    1
    Sugar
    Sugar
    58 percent target mRNA inhibition
    19282453
    SM1094
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-Aminopropyl
    19,20 * 21
    1
    Sugar
    Sugar
    60.2 percent target mRNA inhibition
    19282453
    SM1095
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-Aminopropyl
    3,5,9,19,20 * 21
    1
    Sugar
    Sugar
    50.5 percent target mRNA inhibition
    19282453
    SM1096
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-Aminopropyl
    19,20 * 21
    1
    Sugar
    Sugar
    57.4 percent target mRNA inhibition
    19282453
    SM1097
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-Aminopropyl
    3,5,9,19,20 * 21
    1
    Sugar
    Sugar
    41.6 percent target mRNA inhibition
    19282453
    SM1098
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-Aminopropyl
    16,18
    1
    Sugar
    Sugar
    69.1 percent target mRNA inhibition
    19282453
    SM1099
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-Aminopropyl
    2,4
    1
    Sugar
    Sugar
    52.1 percent target mRNA inhibition
    19282453
    SM1100
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Fluoro* 2-O-Methyl
    2-Aminopropyl
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    1
    Sugar
    Sugar
    40.5 percent target mRNA inhibition
    19282453
    SM1101
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    20
    1
    Sugar
    Sugar
    62 percent target mRNA inhibition
    19282453
    SM1102
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    19
    1
    Sugar
    Sugar
    54.7 percent target mRNA inhibition
    19282453
    SM1103
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    5,19,20
    1
    Sugar
    Sugar
    55.2 percent target mRNA inhibition
    19282453
    SM1104
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,9,15,20,21
    1
    Sugar
    Sugar
    37 percent target mRNA inhibition
    19282453
    SM1105
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-Aminopropyl
    19,20
    1
    Sugar
    Sugar
    44 percent target mRNA inhibition
    19282453
    SM1106
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-Aminopropyl
    5,19,20
    1
    Sugar
    Sugar
    64.3 percent target mRNA inhibition
    19282453