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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 * 18 are 45
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0092
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Cyanoethyl
    18
    1 * 18
    Sugar
    Sugar
    54.8 percent target mRNA inhibition
    19282453
    SM0093
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-O-Methyl* 2-Cyanoethyl
    18
    1 * 18
    Sugar
    Sugar
    55 percent target mRNA inhibition
    19282453
    SM0094
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    2,8,14,17
    1 * 18
    Sugar
    Sugar
    47.8 percent target mRNA inhibition
    19282453
    SM0095
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    5,8,14,17,22
    1 * 18
    Sugar
    Sugar
    24.8 percent target mRNA inhibition
    19282453
    SM0096
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    1,2 * 22
    1 * 18
    Sugar
    Sugar
    54.8 percent target mRNA inhibition
    19282453
    SM0097
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    18,19 * 22
    1 * 18
    Sugar
    Sugar
    33.7 percent target mRNA inhibition
    19282453
    SM0098
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    5,8,11,14,17 * 22
    1 * 18
    Sugar
    Sugar
    6.7 percent target mRNA inhibition
    19282453
    SM0099
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    20,21
    1 * 18
    Sugar
    Sugar
    24.7 percent target mRNA inhibition
    19282453
    SM0100
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    19,20
    1 * 18
    Sugar
    Sugar
    28.3 percent target mRNA inhibition
    19282453
    SM0101
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    1,2,3,18,19,20 * 21
    1 * 18
    Sugar
    Sugar
    57.2 percent target mRNA inhibition
    19282453
    SM0102
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    5,8,11,14 * 21
    1 * 18
    Sugar
    Sugar
    34.7 percent target mRNA inhibition
    19282453
    SM0103
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    5,8,11,14,19,20 * 21
    1 * 18
    Sugar
    Sugar
    51.2 percent target mRNA inhibition
    19282453
    SM0104
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    19,20 * 21
    1 * 18
    Sugar
    Sugar
    55.4 percent target mRNA inhibition
    19282453
    SM0105
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    3,5,9,19,20 * 21
    1 * 18
    Sugar
    Sugar
    59 percent target mRNA inhibition
    19282453
    SM0106
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    19,20 * 21
    1 * 18
    Sugar
    Sugar
    60.3 percent target mRNA inhibition
    19282453
    SM0107
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Cyanoethyl
    3,5,9,19,20 * 21
    1 * 18
    Sugar
    Sugar
    48 percent target mRNA inhibition
    19282453
    SM0108
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    16,18
    1 * 18
    Sugar
    Sugar
    53.5 percent target mRNA inhibition
    19282453
    SM0109
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    2,4
    1 * 18
    Sugar
    Sugar
    39.9 percent target mRNA inhibition
    19282453
    SM0110
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Fluoro* 2-O-Methyl
    2-O-Methyl* 2-Cyanoethyl
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    1 * 18
    Sugar
    Sugar
    18 percent target mRNA inhibition
    19282453
    SM0111
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Cyanoethyl
    20
    1 * 18
    Sugar
    Sugar
    55.5 percent target mRNA inhibition
    19282453
    SM0112
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Cyanoethyl
    19
    1 * 18
    Sugar
    Sugar
    43 percent target mRNA inhibition
    19282453
    SM0113
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Cyanoethyl
    5,19,20
    1 * 18
    Sugar
    Sugar
    37.7 percent target mRNA inhibition
    19282453
    SM0114
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    3,9,15,20,21
    1 * 18
    Sugar
    Sugar
    32.9 percent target mRNA inhibition
    19282453
    SM0115
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Cyanoethyl
    19,20
    1 * 18
    Sugar
    Sugar
    37.8 percent target mRNA inhibition
    19282453
    SM0116
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Cyanoethyl
    5,19,20
    1 * 18
    Sugar
    Sugar
    45.5 percent target mRNA inhibition
    19282453