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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 5-Methylcytosine* Locked nucleic acid are 5
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4726
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    2-Deoxy
    1 * 20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4727
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    Locked nucleic acid
    1 * 20,21
    20,21
    Sugar
    Sugar
    91 percent target mRNA inhibition
    US 8653252 B2
    SM4728
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    Locked nucleic acid
    1 * 20,21
    1,20,21
    Sugar
    Sugar
    35 percent target mRNA inhibition
    US 8653252 B2
    SM4729
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    2-Deoxy
    1 * 2,3,8,12,15,16,20,21
    20,21
    Sugar
    Sugar
    80 percent target mRNA inhibition
    US 8653252 B2
    SM4730
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    5-Methylcytosine* Locked nucleic acid
    Locked nucleic acid
    2 * 2,3,8,12,15,16,20,21
    20,21
    Sugar
    Sugar
    73 percent target mRNA inhibition
    US 8653252 B2