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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 250 - 275

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1608	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Locked nucleic acid	3,5,7,9,20,21 19,20	Sugar Sugar	63.9 percent target mRNA inhibition	19282453
SM1609	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Locked nucleic acid	3,9,13,15,20,21 19,20	Sugar Sugar	76.1 percent target mRNA inhibition	19282453
SM1620	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Locked nucleic acid	3,8,13,15,20,21 19,20	Sugar Sugar	81.8 percent target mRNA inhibition	19282453
SM1621	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Locked nucleic acid	20,21 19,20	Sugar Sugar	86.7 percent target mRNA inhibition	19282453
SM1645	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,15,20,21 18 * 20,21	Sugar Sugar	63.3 percent target mRNA inhibition	19282453
SM1648	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 18 * 20,21	Sugar Sugar	78.5 percent target mRNA inhibition	19282453
SM1652	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	5,20,21 18 * 20,21	Sugar Sugar	70.4 percent target mRNA inhibition	19282453
SM1653	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 18 * 20,21	Sugar Sugar	14.8 percent target mRNA inhibition	19282453
SM1654	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 18 * 20,21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM1665	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 18 * 20,21	Sugar Sugar	6.2 percent target mRNA inhibition	19282453
SM1666	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	20,21 18 * 20,21	Sugar Sugar	63.8 percent target mRNA inhibition	19282453
SM1690	GACGUAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,15,20,21 6 * 20,21	Sugar Sugar	65.2 percent target mRNA inhibition	19282453
SM1693	GACGUAAACG + GCCACAAGUTC ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 6 * 20,21	Sugar Sugar	70.3 percent target mRNA inhibition	19282453
SM1697	GACGTAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	5,20,21 6 * 20,21	Sugar Sugar	60 percent target mRNA inhibition	19282453
SM1698	GACGTAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 6 * 20,21	Sugar Sugar	14.6 percent target mRNA inhibition	19282453
SM1699	GACGUAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 6 * 20,21	Sugar Sugar	16.3 percent target mRNA inhibition	19282453
SM1710	GACGUAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 6 * 20,21	Sugar Sugar	28.1 percent target mRNA inhibition	19282453
SM1711	GACGUAAACGGCCACAAGUTC ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	20,21 6 * 20,21	Sugar Sugar	69.9 percent target mRNA inhibition	19282453
SM1735	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,15,20,21 18 * 20,21	Sugar Sugar	53 percent target mRNA inhibition	19282453
SM1738	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 18 * 20,21	Sugar Sugar	71.9 percent target mRNA inhibition	19282453
SM1742	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	5,20,21 18 * 20,21	Sugar Sugar	63.3 percent target mRNA inhibition	19282453
SM1743	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 18 * 20,21	Sugar Sugar	11.9 percent target mRNA inhibition	19282453
SM1744	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 18 * 20,21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM1755	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 18 * 20,21	Sugar Sugar	26 percent target mRNA inhibition	19282453
SM1756	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGTCGCU	Locked nucleic acid 2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid	20,21 18 * 20,21	Sugar Sugar	61.8 percent target mRNA inhibition	19282453



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