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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid are 409
    Results from 150 - 175
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0976
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,20,21
    4,18
    Sugar
    Sugar
    28.1 percent target mRNA inhibition
    19282453
    SM0977
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    4,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0978
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,9,13,15,20,21
    4,18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0989
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,8,13,15,20,21
    4,18
    Sugar
    Sugar
    1.4 percent target mRNA inhibition
    19282453
    SM0990
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20,21
    4,18
    Sugar
    Sugar
    79.1 percent target mRNA inhibition
    19282453
    SM1014
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,9,15,20,21
    3,4,18
    Sugar
    Sugar
    70.2 percent target mRNA inhibition
    19282453
    SM1017
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,9,13,15,20,21
    3,4,18
    Sugar
    Sugar
    67.8 percent target mRNA inhibition
    19282453
    SM1021
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,20,21
    3,4,18
    Sugar
    Sugar
    72.8 percent target mRNA inhibition
    19282453
    SM1022
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,5,7,9,20,21
    3,4,18
    Sugar
    Sugar
    1.8 percent target mRNA inhibition
    19282453
    SM1023
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,9,13,15,20,21
    3,4,18
    Sugar
    Sugar
    4.2 percent target mRNA inhibition
    19282453
    SM1034
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    3,8,13,15,20,21
    3,4,18
    Sugar
    Sugar
    10.7 percent target mRNA inhibition
    19282453
    SM1035
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20,21
    3,4,18
    Sugar
    Sugar
    70.5 percent target mRNA inhibition
    19282453
    SM1059
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    3,9,15,20,21
    20,21
    Sugar
    Sugar
    89.7 percent target mRNA inhibition
    19282453
    SM1062
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    90 percent target mRNA inhibition
    19282453
    SM1066
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    5,20,21
    20,21
    Sugar
    Sugar
    89.5 percent target mRNA inhibition
    19282453
    SM1067
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    3,5,7,9,20,21
    20,21
    Sugar
    Sugar
    84.6 percent target mRNA inhibition
    19282453
    SM1068
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    85 percent target mRNA inhibition
    19282453
    SM1079
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    3,8,13,15,20,21
    20,21
    Sugar
    Sugar
    88.3 percent target mRNA inhibition
    19282453
    SM1080
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminoethyl
    20,21
    20,21
    Sugar
    Sugar
    88.4 percent target mRNA inhibition
    19282453
    SM1104
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,9,15,20,21
    1
    Sugar
    Sugar
    37 percent target mRNA inhibition
    19282453
    SM1107
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,9,13,15,20,21
    1
    Sugar
    Sugar
    53.9 percent target mRNA inhibition
    19282453
    SM1111
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    5,20,21
    1
    Sugar
    Sugar
    30 percent target mRNA inhibition
    19282453
    SM1112
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,5,7,9,20,21
    1
    Sugar
    Sugar
    8.9 percent target mRNA inhibition
    19282453
    SM1113
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,9,13,15,20,21
    1
    Sugar
    Sugar
    8.8 percent target mRNA inhibition
    19282453
    SM1124
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-Aminopropyl
    3,8,13,15,20,21
    1
    Sugar
    Sugar
    12.8 percent target mRNA inhibition
    19282453