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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Oxetane-Locked nucleic acid are 96
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0017
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    2-O-Methyl
    16,18
    2
    Sugar
    Sugar
    81.2 percent target mRNA inhibition
    19282453
    SM0018
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    2-O-Methyl
    2,4
    2
    Sugar
    Sugar
    65.2 percent target mRNA inhibition
    19282453
    SM0063
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    16,18
    1 * 21
    Sugar
    Sugar
    90 percent target mRNA inhibition
    19282453
    SM0064
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    2,4
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0108
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    16,18
    1 * 18
    Sugar
    Sugar
    53.5 percent target mRNA inhibition
    19282453
    SM0109
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    2,4
    1 * 18
    Sugar
    Sugar
    39.9 percent target mRNA inhibition
    19282453
    SM0153
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    16,18
    1,2
    Sugar
    Sugar
    62.6 percent target mRNA inhibition
    19282453
    SM0154
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    2,4
    1,2
    Sugar
    Sugar
    49.6 percent target mRNA inhibition
    19282453
    SM0198
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    16,18
    20,21
    Sugar
    Sugar
    92.2 percent target mRNA inhibition
    19282453
    SM0199
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    2,4
    20,21
    Sugar
    Sugar
    89.1 percent target mRNA inhibition
    19282453
    SM0243
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    16,18
    5,8,11,14,17,20
    Sugar
    Sugar
    33.8 percent target mRNA inhibition
    19282453
    SM0244
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    2,4
    5,8,11,14,17,20
    Sugar
    Sugar
    6.2 percent target mRNA inhibition
    19282453
    SM0288
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    16,18
    3,6,14,18,20,21
    Sugar
    Sugar
    80.3 percent target mRNA inhibition
    19282453
    SM0289
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    2,4
    3,6,14,18,20,21
    Sugar
    Sugar
    76.6 percent target mRNA inhibition
    19282453
    SM0333
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    16,18
    18,19,20 * 21
    Sugar
    Sugar
    86 percent target mRNA inhibition
    19282453
    SM0334
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    2,4
    18,19,20 * 21
    Sugar
    Sugar
    85.7 percent target mRNA inhibition
    19282453
    SM0378
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    16,18
    2,18,19,20 * 21
    Sugar
    Sugar
    83.4 percent target mRNA inhibition
    19282453
    SM0379
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    2,4
    2,18,19,20 * 21
    Sugar
    Sugar
    78.5 percent target mRNA inhibition
    19282453
    SM0423
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    16,18
    3,18,19,20 * 21
    Sugar
    Sugar
    87.1 percent target mRNA inhibition
    19282453
    SM0424
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    2,4
    3,18,19,20 * 21
    Sugar
    Sugar
    78.2 percent target mRNA inhibition
    19282453
    SM0468
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    16,18
    2,9,18,19,20 * 21
    Sugar
    Sugar
    50.3 percent target mRNA inhibition
    19282453
    SM0469
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    2,4
    2,9,18,19,20 * 21
    Sugar
    Sugar
    38.7 percent target mRNA inhibition
    19282453
    SM0513
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    2-Aminoethoxymethyl* 2-Deoxy
    16,18
    18,19 * 21
    Sugar
    Sugar
    55.3 percent target mRNA inhibition
    19282453
    SM0514
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    2-Aminoethoxymethyl* 2-Deoxy
    2,4
    18,19 * 21
    Sugar
    Sugar
    52.4 percent target mRNA inhibition
    19282453
    SM0558
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Oxetane-Locked nucleic acid
    2-Aminopropoxymethyl* 2-Deoxy
    16,18
    18,19 * 21
    Sugar
    Sugar
    57.9 percent target mRNA inhibition
    19282453