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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for UnLocked nucleic acid* Locked nucleic acid are 96
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0039	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid* Locked nucleic acid 2-O-Methyl	5 * 20,21 2	Sugar Sugar	11 percent target mRNA inhibition	19282453
SM0040	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid* Locked nucleic acid 2-O-Methyl	10 * 21,22 2	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0085	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid 2-O-Methyl* 2-Aminoethyl	5 * 20,21 1 * 21	Sugar Sugar	9.6 percent target mRNA inhibition	19282453
SM0086	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid 2-O-Methyl* 2-Aminoethyl	10 * 21,22 1 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0130	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid 2-O-Methyl* 2-Cyanoethyl	5 * 20,21 1 * 18	Sugar Sugar	0.9 percent target mRNA inhibition	19282453
SM0131	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid 2-O-Methyl* 2-Cyanoethyl	10 * 21,22 1 * 18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0175	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	5 * 20,21 1,2	Sugar Sugar	8.3 percent target mRNA inhibition	19282453
SM0176	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	10 * 21,22 1,2	Sugar Sugar	7.2 percent target mRNA inhibition	19282453
SM0220	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	5 * 20,21 20,21	Sugar Sugar	85.4 percent target mRNA inhibition	19282453
SM0221	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	10 * 21,22 20,21	Sugar Sugar	72.3 percent target mRNA inhibition	19282453
SM0265	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	5 * 20,21 5,8,11,14,17,20	Sugar Sugar	5.7 percent target mRNA inhibition	19282453
SM0266	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	10 * 21,22 5,8,11,14,17,20	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0310	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	5 * 20,21 3,6,14,18,20,21	Sugar Sugar	44.2 percent target mRNA inhibition	19282453
SM0311	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid* Locked nucleic acid Altritol nucleic acid	10 * 21,22 3,6,14,18,20,21	Sugar Sugar	11 percent target mRNA inhibition	19282453
SM0355	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5 * 20,21 18,19,20 * 21	Sugar Sugar	45.1 percent target mRNA inhibition	19282453
SM0356	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	10 * 21,22 18,19,20 * 21	Sugar Sugar	6.2 percent target mRNA inhibition	19282453
SM0400	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5 * 20,21 2,18,19,20 * 21	Sugar Sugar	8.7 percent target mRNA inhibition	19282453
SM0401	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	10 * 21,22 2,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0445	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5 * 20,21 3,18,19,20 * 21	Sugar Sugar	19.5 percent target mRNA inhibition	19282453
SM0446	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	10 * 21,22 3,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0490	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5 * 20,21 2,9,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0491	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	10 * 21,22 2,9,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0535	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	5 * 20,21 18,19 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0536	GACGUAAACCGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	10 * 21,22 18,19 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0580	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid* Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	5 * 20,21 18,19 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453



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